Columbia University, Department of Biomedical Engineering, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, New York 10027.
J Biomed Opt. 2013 Sep;18(9):096012. doi: 10.1117/1.JBO.18.9.096012.
Diffuse optical tomography (DOT) is a noninvasive, nonionizing imaging modality that uses near-infrared light to visualize optically relevant chromophores. A recently developed dynamic DOT imaging system enables the study of hemodynamic effects in the breast during a breath-hold. Dynamic DOT imaging was performed in a total of 21 subjects (age 54±10 years) including 3 healthy subjects and 18 subjects with benign (n=8) and malignant (n=14) masses. Three-dimensional time-series images of the percentage change in oxygenated and deoxygenated hemoglobin concentrations ([HbO2] and [Hb]) from baseline are obtained over the course of a breath-hold. At a time point of 15 s following the end of the breath-hold, [Hb] in healthy breasts has returned to near-baseline values (1.6%±0.5%), while tumor-bearing breasts have increased levels of [Hb] (6.8%±3.6%, p<0.01). Further, healthy subjects have a higher correlation between the breasts over the course of the breath-hold as compared with the subjects with breast cancer (healthy: 0.96±0.02; benign: 0.89±0.02; malignant: 0.78±0.23, p<0.05). Therefore this study shows that dynamic features extracted from DOT measurements can differentiate healthy and diseased breast tissues. These features provide a physiologic method for identifying breast cancer without the need for ionizing radiation.
漫射光学断层成像（DOT）是一种非侵入性、非电离成像方式，利用近红外光来可视化与光学相关的发色团。最近开发的动态 DOT 成像系统能够在屏气过程中研究乳房中的血液动力学效应。在总共 21 名受试者（年龄 54±10 岁）中进行了动态 DOT 成像，包括 3 名健康受试者和 18 名良性（n=8）和恶性（n=14）肿块受试者。在屏气过程中，获得了含氧和去氧血红蛋白浓度变化百分比的三维时间序列图像（[HbO2]和[Hb]）。在屏气结束后 15 秒的时间点，健康乳房中的[Hb]已恢复到接近基线值（1.6%±0.5%），而肿瘤乳房中的[Hb]水平升高（6.8%±3.6%，p<0.01）。此外，与乳腺癌患者相比，健康受试者在屏气过程中乳房之间的相关性更高（健康：0.96±0.02；良性：0.89±0.02；恶性：0.78±0.23，p<0.05）。因此，这项研究表明，从 DOT 测量中提取的动态特征可以区分健康和患病的乳房组织。这些特征为识别乳腺癌提供了一种无需电离辐射的生理方法。
