Natali P G, Mottolese M, Donnorso R P, Buffa R, Bussolati G, Coggi G, Corradi G, Coscia-Porrazzi L, Ferretti M, Rondanelli E
Lab. Immunologia e Citopatologia, 1st Regina Elena, Rome, Italy.
Int J Cancer. 1990 Jan 15;45(1):12-5. doi: 10.1002/ijc.2910450104.
Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% and an accuracy of 92.4%. The predictive value of a positive and a negative finding were 98.4% and 85.57% respectively. Comparison between the cytological and immunocytochemical diagnosis displayed a higher sensitivity, accuracy and predictive value of a negative result with the latter method (p less than 0.01). Our findings clearly indicate that immunocytochemical methods can complement and improve the diagnostic accuracy of FNA cytology of breast nodules.
细针穿刺（FNA）细胞学检查越来越多地与体格检查和乳腺钼靶检查相结合，用于乳腺结节的术前诊断。在本研究中，我们将一种免疫细胞化学检测方法提交进行多中心验证，该方法使用针对乳腺肿瘤相关抗原（BTAA）的单克隆抗体（MAb）来诊断乳腺癌。这项对846例FNA进行评估的分析结果表明，该免疫检测的敏感性为88.62%，特异性为97.9%，准确性为92.4%。阳性和阴性结果的预测值分别为98.4%和85.57%。细胞学诊断与免疫细胞化学诊断之间的比较显示，后一种方法具有更高的敏感性、准确性和阴性结果预测值（p小于0.01）。我们的研究结果清楚地表明，免疫细胞化学方法可以补充并提高乳腺结节FNA细胞学检查的诊断准确性。
