CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing 100190, China.
Adv Mater. 2013 Jul 26;25(28):3869-80. doi: 10.1002/adma.201301890. Epub 2013 Jun 6.
While thermo-chemotherapy has proved to be effective in optimizing the efficacies of cancer treatments, traditional chemotherapy is subject to adverse side effects and heat delivery is often challenging in operation. Some photothermal inorganic nanoparticles responsive to near infrared light provide new opportunities for simultaneous and targeted delivery of heat and chemotherapeutics to the tumor sites in pursuit of synergistic effects for efficacy enhancement. The state of the art of nanoparticle-induced thermo-chemotherapy is summarized and the advantages and challenges of the major nanoplatforms based on gold nanoparticles, carbon nanomaterials, palladium nanosheets, and copper-based nanocrystals are highlighted. In addition, the optical-imaging potentials of the nanoplatforms that may endow them with imaging-guided therapy and therapeutic-result-monitoring capabilities are also briefly discussed.
热化疗已被证明可有效优化癌症治疗效果，但传统化疗会引发不良反应，且其热传递操作往往具有挑战性。一些对近红外光有响应的光热无机纳米粒子为在肿瘤部位同时递送电疗和化疗药物以实现增效作用提供了新的机会。本文总结了纳米粒子诱导的热化疗的最新进展，并重点介绍了基于金纳米粒子、碳纳米材料、钯纳米片和铜基纳米晶体的主要纳米平台的优势和挑战。此外，本文还简要讨论了这些纳米平台的光学成像潜力，这些潜力可能使它们具有成像引导治疗和治疗结果监测能力。
