Mansournia Aysan, Nobari Nasim, Ghanbary Fatemeh, Khezri Behrooz
Department of Physic, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
Department of Chemistry, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
Iran J Pharm Res. 2025 Apr 29;24(1):e157301. doi: 10.5812/ijpr-157301. eCollection 2025 Jan-Dec.
Cancer is a deadly and multifaceted disease that poses a significant challenge to treatment due to its heterogeneity and ability to adapt and evolve. Despite advancements in research and medicine, the development of effective treatment options remains a major obstacle in the battle against cancer. Manganese oxide (MnO) and iron (III) oxide (FeO) nanoparticles (NPs) are increasingly used for numerous new applications in modern industrial sectors. However, the toxic and treatment impact of MnO and FeO NPs has not been clearly elucidated on human cell lines at the cellular and molecular levels.
This study aimed to assess the potential cytotoxic effect of combining infrared (IR) laser therapy with MnO and FeO nanoparticles on breast and colorectal cancer cells for cancer treatment.
We treated the cancer cells with MnO and FeO NPs and then exposed them to IR radiation for 6, 12, 24, 48, and 72 hours to investigate the effectiveness of this cancer treatment approach. To evaluate cytotoxicity, we conducted assessments on Skbr3 and HT29 cancer cells, both individually and in combination, using various methods.
The findings indicate that despite the inherent toxicity of NPs and IR laser radiation on cancer cells, the utilization of MnO and FeO NPs in conjunction with IR laser radiation treatment had the highest cytotoxic impact on cancer cells.
These findings suggest that using MnO and FeO NPs in combination with IR laser therapy has great potential as an effective method for reducing the population of cancer cells.This revision maintains the original content while ensuring clarity and adherence to the AMA style guidelines.
癌症是一种致命且多方面的疾病，因其异质性以及适应和进化的能力，对治疗构成重大挑战。尽管在研究和医学方面取得了进展，但开发有效的治疗方案仍然是抗癌斗争中的一个主要障碍。氧化锰（MnO）和氧化铁（III）（FeO）纳米颗粒（NPs）在现代工业领域越来越多地用于众多新应用。然而，MnO和FeO NPs对人类细胞系在细胞和分子水平上的毒性和治疗影响尚未明确阐明。
本研究旨在评估将红外（IR）激光疗法与MnO和FeO纳米颗粒联合用于乳腺癌和结肠直肠癌细胞治疗癌症的潜在细胞毒性作用。
我们用MnO和FeO NPs处理癌细胞，然后将它们暴露于IR辐射6、12、24、48和72小时，以研究这种癌症治疗方法的有效性。为了评估细胞毒性，我们使用各种方法对Skbr3和HT29癌细胞单独和联合进行了评估。
研究结果表明，尽管NPs和IR激光辐射对癌细胞具有固有毒性，但将MnO和FeO NPs与IR激光辐射治疗联合使用对癌细胞具有最高的细胞毒性影响。
这些发现表明，将MnO和FeO NPs与IR激光疗法联合使用作为减少癌细胞数量的有效方法具有巨大潜力。本次修订在确保清晰度和符合AMA风格指南的同时保留了原始内容。
