Downer Brian, Zanjani Faika, Fardo David W
Corresponding author: Graduate Center for Gerontology, University of Kentucky College of Public Health, 740 South Limestone, J524 KY Clinic, Lexington, KY, 40536-0284, USA.
Alcohol Alcohol. 2014 Jan-Feb;49(1):17-22. doi: 10.1093/alcalc/agt144. Epub 2013 Sep 18.
The aim of the study was to determine whether the trajectory of learning and memory is modified according to an interaction between midlife or late life alcohol consumption status and the presence of one or more APOE e4 alleles.
This was a secondary analysis of cognitive, genetic and alcohol consumption data collected from members of the Framingham Heart Study Offspring Cohort.
Light and moderate alcohol consumption during late life was associated with greater decline in learning and memory among APOE e4 carriers, whereas light and moderate alcohol consumption was associated with an increase in learning and memory among non-APOE e4 carriers. There was not a significant interaction between midlife alcohol consumption status and APOE e4 on the trajectory of learning and memory.
Light to moderate alcohol consumption during late life may protect against a decline in learning and memory for non-APOE e4 allele carriers, but not for older adults who carry one or more APOE e4 alleles.
本研究旨在确定学习与记忆轨迹是否会根据中年或晚年饮酒状况与一个或多个APOE e4等位基因的存在之间的相互作用而发生改变。
这是对从弗雷明汉心脏研究后代队列成员收集的认知、基因和饮酒数据进行的二次分析。
晚年轻度和中度饮酒与APOE e4携带者的学习和记忆能力更大程度下降有关，而轻度和中度饮酒与非APOE e4携带者的学习和记忆能力增加有关。中年饮酒状况与APOE e4在学习和记忆轨迹上没有显著的相互作用。
晚年轻度至中度饮酒可能预防非APOE e4等位基因携带者的学习和记忆能力下降，但对于携带一个或多个APOE e4等位基因的老年人则不然。
