牙周炎、糖尿病与失衡的氧化还原平衡：一个统一轴
Periodontitis, diabetes mellitus, and the lopsided redox balance: A unifying axis.
作者信息
Pendyala Gowri, Thomas Biju, Joshi Saurabh
机构信息
Department of Periodontics, Rural Dental College, Loni, India.
出版信息
J Indian Soc Periodontol. 2013 May;17(3):338-44. doi: 10.4103/0972-124X.115661.
AIM
The aim of present study was to evaluate and compare the total antioxidant capacity in the saliva of type 2 diabetes mellitus (DM) patients and healthy subjects, with and without periodontal disease.
MATERIALS AND METHODS
The study was designed as a case-control study, comprising of 120 male subjects, who were divided into four groups of 30 patients each. Group I: Thirty type 2 diabetic males with periodontal disease; Group II: Thirty type 2 diabetic males without periodontal disease; Group III: Thirty healthy males with periodontal disease; Group IV: Thirty healthy males without periodontal disease. After clinical measurement and sampling, the total antioxidant capacities in the saliva of type 2 diabetic and healthy men were determined, and the data were tested by non-parametric tests. The total antioxidant capacity of the clinical samples was determined spectrophotometrically.
RESULTS
The total antioxidant capacity in the saliva was the lowest in type 2 diabetic males with periodontal disease. The results were statistically significant.
CONCLUSION
The findings of our study finally conclude that the salivary total antioxidant capacity is affected in type 2 diabetic males, in addition to the impact of periodontal disease, and hence, can be used as a useful marker of periodontitis in healthy and diabetic patients.
目的
本研究旨在评估和比较2型糖尿病（DM）患者和健康受试者在有或无牙周疾病情况下唾液中的总抗氧化能力。
材料与方法
本研究设计为病例对照研究，包括120名男性受试者，分为四组，每组30名患者。第一组：30名患有牙周疾病的2型糖尿病男性；第二组：30名无牙周疾病的2型糖尿病男性；第三组：30名患有牙周疾病的健康男性；第四组：30名无牙周疾病的健康男性。经过临床测量和采样后，测定2型糖尿病男性和健康男性唾液中的总抗氧化能力，并采用非参数检验对数据进行检验。临床样本的总抗氧化能力通过分光光度法测定。
结果
患有牙周疾病的2型糖尿病男性唾液中的总抗氧化能力最低。结果具有统计学意义。
结论
我们的研究结果最终得出结论，2型糖尿病男性的唾液总抗氧化能力除受牙周疾病影响外，还受到糖尿病的影响，因此，可作为健康和糖尿病患者牙周炎的有用标志物。
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