Wang Yue, Andrukhov Oleh, Rausch-Fan Xiaohui
Department of Periodontology and Competence Center for Periodontal Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Department of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Front Physiol. 2017 Nov 13;8:910. doi: 10.3389/fphys.2017.00910. eCollection 2017.
Periodontitis is a common inflammatory disease, which is initiated by bacterial infection and subsequently progressed by aberrant host response. It can result in the destruction of teeth supporting tissues and have an influence on systemic health. When periodontitis occurs, reactive oxygen species, which are overproduced mostly by hyperactive neutrophils, could not be balanced by antioxidant defense system and cause tissues damage. This is characterized by increased metabolites of lipid peroxidation, DNA damage and protein damage. Local and systemic activities of antioxidants can also be influenced by periodontitis. Total antioxidant capacity, total oxidant status and oxidative stress index have been used to evaluate the oxidative stress associated with periodontitis. Studies have confirmed that inflammatory response in periodontitis is associated with an increased local and systemic oxidative stress and compromised antioxidant capacity. Our review focuses on increased oxidative stress in periodontal disease, specifically, on the relationship between the local and systemic biomarkers of oxidative stress and periodontitis and their association with the pathogenesis of periodontitis. Also, the relationship between periodontitis and systemic inflammation, and the effects of periodontal therapy on oxidative stress parameters will be discussed.
牙周炎是一种常见的炎症性疾病，由细菌感染引发，随后因宿主异常反应而进展。它可导致牙齿支持组织的破坏，并对全身健康产生影响。当牙周炎发生时，主要由过度活跃的中性粒细胞过度产生的活性氧无法被抗氧化防御系统平衡，从而导致组织损伤。其特征是脂质过氧化代谢产物增加、DNA损伤和蛋白质损伤。抗氧化剂的局部和全身活性也会受到牙周炎的影响。总抗氧化能力、总氧化剂状态和氧化应激指数已被用于评估与牙周炎相关的氧化应激。研究证实，牙周炎中的炎症反应与局部和全身氧化应激增加以及抗氧化能力受损有关。我们的综述重点关注牙周疾病中氧化应激的增加，具体而言，关注氧化应激的局部和全身生物标志物与牙周炎之间的关系及其与牙周炎发病机制的关联。此外，还将讨论牙周炎与全身炎症之间的关系以及牙周治疗对氧化应激参数的影响。
