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从厚皮马拉色菌G-14生产抗高血压血管紧张素I转换酶抑制剂

Production of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor from Malassezia pachydermatis G-14.

作者信息

Jeong Seung Chan, Kim Jae Ho, Kim Na-Mi, Lee Jong Soo

机构信息

Department of Genetic Engineering and Bio-medicinal Resource Research Center, Paichai University, Daejeon 302-735, Korea.

出版信息

Mycobiology. 2005 Sep;33(3):142-6. doi: 10.4489/MYCO.2005.33.3.142. Epub 2005 Sep 30.

DOI:10.4489/MYCO.2005.33.3.142
PMID:24049490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3774874/
Abstract

To produce a novel antihypertensive angiotensin I-converting enzyme (ACE) inhibitor from yeast, a yeast isolate, designated G-14 showing the highest ACE inhibitory activity was obtained and identified as Malassezia pachydermatis based on morphological, biochemical and cultural characteristics. The maximal extracellular ACE inhibitor production was obtained from M. pachydermatis G-14 when the strain was cultured in YEPD medium containing 0.5% yeast extract, 3.0% peptone and 2.0% glucose at 30℃ for 24 h and the final ACE inhibitory activity was 48.9% under the above condition.

摘要

为了从酵母中生产一种新型抗高血压血管紧张素I转换酶（ACE）抑制剂，获得了一株表现出最高ACE抑制活性的酵母分离株，命名为G-14，并根据形态学、生化和培养特性鉴定为厚皮马拉色菌。当该菌株在含有0.5%酵母提取物、3.0%蛋白胨和2.0%葡萄糖的YEPD培养基中于30℃培养24小时时，厚皮马拉色菌G-14产生的细胞外ACE抑制剂产量最高，在上述条件下最终的ACE抑制活性为48.9%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/94433fcce666/mb-33-142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/0fc9303078d2/mb-33-142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/3b0eeb9247c1/mb-33-142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/94433fcce666/mb-33-142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/0fc9303078d2/mb-33-142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/3b0eeb9247c1/mb-33-142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9388/3774874/94433fcce666/mb-33-142-g003.jpg

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