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细菌性阴道病诱发的反应性关节炎:通过有效治疗进行预防

Reactive arthritis induced by bacterial vaginosis: prevention with an effective treatment.

作者信息

Aminzadeh Zohreh, Fadaeian Afsaneh

机构信息

Professor of Medicine, Shahid Beheshti University of Medical Sciences Consultant ID Physician, Loghman Hakim Hospital, Tehran, Iran.

出版信息

Int J Prev Med. 2013 Jul;4(7):841-4.

PMID:24049604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3775225/
Abstract

We report a 42-year-old woman with reactive arthritis induced by bacterial vaginosis who presented with oligoarthritis with an additive form, arthralgia, and enthesitis. She hasn't had a history of diarrhea or dysuria or vaginal secretion, or sexually transmitted infections (STIs). The laboratory tests were normal except for a high erythrocyte sedimentation rate (ESR). Her pelvic examination revealed homogeneous white grey and malodorous vaginal discharge on the vaginal wall and Pap smear and Gram-stained smear of vaginal swab was consistent with bacterial vaginosis. She responded to metronidazole therapy and her six-month follow up hasn't shown recurrence of arthritis. As reactive arthritis (ReA) is a paradigm of a rheumatic disease in which the initiating infectious cause is known, so early use of antimicrobial drugs may prevent the development of musculoskeletal symptoms which are triggered by infections.

摘要

我们报告了一名42岁患有细菌性阴道病诱发的反应性关节炎的女性,她表现为少关节炎(呈叠加型)、关节痛和附着点炎。她既往没有腹泻、排尿困难、阴道分泌物异常或性传播感染(STIs)的病史。除红细胞沉降率(ESR)升高外,实验室检查均正常。她的盆腔检查发现阴道壁有均匀的灰白色且有异味的阴道分泌物,阴道拭子的巴氏涂片和革兰氏染色涂片结果与细菌性阴道病相符。她对甲硝唑治疗有反应,六个月的随访未显示关节炎复发。由于反应性关节炎(ReA)是一种已知起始感染病因的风湿性疾病范例,因此早期使用抗菌药物可能预防由感染引发的肌肉骨骼症状的发展。

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本文引用的文献

1
Sexually transmitted diseases treatment guidelines, 2010.性传播疾病治疗指南,2010 年。
MMWR Recomm Rep. 2010 Dec 17;59(RR-12):1-110.
2
Treatment considerations for bacterial vaginosis and the risk of recurrence.细菌性阴道病的治疗注意事项及复发风险。
J Womens Health (Larchmt). 2009 Dec;18(12):1997-2004. doi: 10.1089/jwh.2008.1088.
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Reactive arthritis: a review.反应性关节炎:综述
J Adolesc Health. 2009 Apr;44(4):309-15. doi: 10.1016/j.jadohealth.2008.12.007. Epub 2009 Feb 12.
4
Predisposing factors for bacterial vaginosis, treatment efficacy and pregnancy outcome among term deliveries; results from a preterm delivery study.足月分娩中细菌性阴道病的易感因素、治疗效果及妊娠结局;一项早产研究的结果
BMC Womens Health. 2007 Oct 22;7:20. doi: 10.1186/1472-6874-7-20.
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The Pap smear for detection of bacterial vaginosis.用于检测细菌性阴道病的巴氏涂片检查。
Int J Gynaecol Obstet. 2007 Jul;98(1):20-3. doi: 10.1016/j.ijgo.2007.03.010. Epub 2007 Apr 26.
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Campylobacter reactive arthritis: a systematic review.弯曲杆菌反应性关节炎:一项系统评价
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Infection and musculoskeletal conditions: Reactive arthritis.感染与肌肉骨骼疾病:反应性关节炎。
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Bacterial vaginosis: comparison of Pap smear and microbiological test results.细菌性阴道病:巴氏涂片与微生物学检测结果的比较
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Reactive arthritis induced by Gardnerella vaginalis.阴道加德纳菌诱发的反应性关节炎。
Clin Exp Rheumatol. 2002 Sep-Oct;20(5):732-3.
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Diagnosing reactive arthritis: role of clinical setting in the value of serologic and microbiologic assays.反应性关节炎的诊断:临床背景在血清学和微生物学检测价值中的作用
Arthritis Rheum. 2002 Feb;46(2):319-27. doi: 10.1002/art.504.