J Clin Invest. 2013 Oct;123(10):4139-41. doi: 10.1172/JCI71944. Epub 2013 Sep 24.
The distal nephron is composed of two main cell types: principal cells and intercalated cells. These cells have distinct morphologic features that allow them to be readily distinguished by light microscopy, as well as distinct suites of proteins that facilitate cell-specific transport properties. In this issue of the JCI, Gueutin and colleagues describe a new mechanism by which β-intercalated cells, via release of ATP and prostaglandin E2 (PGE2), influence the activity of transporters in principal cells.
主细胞和闰细胞。这些细胞具有独特的形态特征,通过光镜很容易区分,并且具有独特的蛋白质套件,促进细胞特异性的转运特性。在本期 JCI 中,Gueutin 及其同事描述了β闰细胞通过释放 ATP 和前列腺素 E2(PGE2)影响主细胞转运蛋白活性的新机制。