当宿主防御出现差错时：脓毒症诱导的免疫抑制建模
When host defense goes awry: Modeling sepsis-induced immunosuppression.
作者信息
Hu Scott B, Zider Alexander, Deng Jane C
机构信息
Division of Pulmonary and Critical Care Medicine, Los Angeles, CA.
出版信息
Drug Discov Today Dis Models. 2012;9(1):e33-e38. doi: 10.1016/j.ddmod.2011.09.001.
Abstract
Sepsis is associated with an initial hyperinflammatory state; however, therapeutic trials targeting the inflammatory response have yielded disappointing results. It is now appreciated that septic patients often undergo a period of relative immunosuppression, rendering them susceptible to secondary infections. Interest in this phenomenon has led to the development of animal models to study the immune dysfunction of sepsis. In this review, we analyze the available models of sepsis-induced immunosuppression.
摘要
脓毒症与初始的高炎症状态相关；然而，针对炎症反应的治疗试验结果令人失望。现在人们认识到，脓毒症患者常经历一段相对免疫抑制期，使他们易患继发性感染。对这一现象的关注促使了用于研究脓毒症免疫功能障碍的动物模型的开发。在本综述中，我们分析了现有的脓毒症诱导免疫抑制模型。
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