Department of Pediatrics, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA ; Division of Hematology/Oncology, Howard Hughes Medical Institute/Boston Children's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA ; Harvard Stem Cell Institute, Holyoke Center, Suite 727W, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA.
Stem Cell Reports. 2013 Jun 4;1(1):5-17. doi: 10.1016/j.stemcr.2013.05.001.
Cellular reprogramming was recently "crowned" with the award of the Nobel Prize to two of its groundbreaking researchers, Sir John Gurdon and Shinya Yamanaka. The recent link between reprogramming and stem cells makes this appear almost a new field of research, but its historical roots have actually spanned more than a century. Here, the Nobel Prize in Physiology or Medicine 2012 is placed in its historical context.
细胞重编程最近因其两位开创性研究人员约翰·格登爵士和山中伸弥获得诺贝尔奖而“加冕”。最近的重编程和干细胞之间的联系使得这一领域几乎成为一个新的研究领域，但实际上其历史根源可以追溯到一个多世纪以前。在这里，将 2012 年诺贝尔生理学或医学奖置于其历史背景下进行介绍。
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