Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA.
Cell. 2012 Dec 7;151(6):1151-4. doi: 10.1016/j.cell.2012.11.016.
The 2012 Nobel Prize in Medicine or Physiology recognizes the architects of two of the great paradigm-shifting discoveries of the last half-century of biology. In experiments performed nearly 50 years apart, Gurdon and Yamanaka made feasible the reawakening of pluripotency inherent in all cells and challenged forever our notions of cellular identity.
2012 年诺贝尔医学或生理学奖授予了两位具有划时代意义的生物科学发现的奠基人。这两项发现相隔近 50 年,分别由格登和山中伸弥完成。他们的实验使所有细胞中固有全能性的重新激活成为可能,并永远改变了我们对细胞身份的看法。