Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Expert Rev Med Devices. 2013 Sep;10(5):675-84. doi: 10.1586/17434440.2013.827529.
Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future.
最近的出版物表明，α-半水硫酸钙这种水合物中密度最大的形式与羟基磷灰石（HA）颗粒的结合，在各种应用中都能取得良好的临床效果。由于该材料在整个体积中都能转化为骨骼，而不仅仅是从表面向内逐渐取代，因此它具有很大的作为骨替代物的潜力。在植入材料周围观察到了对成骨至关重要的蛋白质的释放，据推测这是由于硫酸钙相的快速溶解，以及 HA 的骨传导性和生物活性。在糖尿病足感染中，载有抗生素的骨传导性 HA/硫酸钙材料已成功应用，并且由于其可注射性，该应用具有微创、简便和精确的特点。它是未来的一种骨替代物。
