Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi, Fukuoka, 812-8532, Japan.
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa, 761-0395, Japan.
J Mater Sci Mater Med. 2018 Sep 27;29(10):151. doi: 10.1007/s10856-018-6162-1.
Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.
尽管八钙磷灰石 (OCP) 粉末和胶原/明胶复合材料显示出作为骨替代物的良好潜力，但迄今为止尚未制备出 OCP 块。在这项研究中，通过使用半水硫酸钙 (CSH) 块作为前体的溶解-沉淀反应来评估制备 OCP 块的可行性。当块浸入磷酸盐盐溶液中时，其组成变为 OCP，但其结构得以保留。OCP 块的直径拉伸强度 (DTS) 为 1.0±0.2 MPa。OCP 块的大孔率和微孔率分别为 33.4±4.5%和 69.0±1.6%。新骨很好地附着在 OCP 块上，植入后 2 周，该块被部分骨取代。植入后 4 周，OCP 块的表面几乎被新骨覆盖，并且约 30%的块被新骨取代，而用作对照的羟基磷灰石 (HAp) 块则没有观察到骨取代。结论是 OCP 块具有作为人工骨替代物的潜在适用性。
