Giebink G S, Batalden P B, Le C T, Lassman F M, Buran D J, Seltz A E
University of Minnesota Otitis Media Research Center, Department of Pediatrics, Minneapolis.
Pediatr Infect Dis J. 1990 Jan;9(1):33-40. doi: 10.1097/00006454-199001000-00008.
A randomized, controlled clinical trial was conducted in 76 children to evaluate the efficacy of trimethoprim-sulfamethoxazole for 4 weeks, prednisone for 2 weeks and aluminum ibuprofen suspension for 2 weeks in resolving chronic otitis media with effusion which had persisted for more than 8 weeks. After 2 weeks of treatment resolution rates of chronic otitis media with effusion in the prednisone and trimethoprim-sulfamethoxazole groups were significantly greater than those in the control (no treatment) and ibuprofen groups. After 4 weeks the differences in resolution rates between the control, trimethoprim-sulfamethoxazole and prednisone groups became smaller. After 12 months of follow-up, differences in hearing sensitivity among study groups were not statistically significant, although 83% of patients had a 15-dB or greater hearing loss. Therefore short term antimicrobial and antiinflammatory treatment did not appear to have a long lasting effect on chronic middle ear inflammation.
对76名儿童进行了一项随机对照临床试验，以评估甲氧苄啶-磺胺甲恶唑治疗4周、泼尼松治疗2周以及铝布洛芬混悬液治疗2周对缓解持续超过8周的慢性分泌性中耳炎的疗效。治疗2周后，泼尼松组和甲氧苄啶-磺胺甲恶唑组慢性分泌性中耳炎的缓解率显著高于对照组（未治疗组）和布洛芬组。4周后，对照组、甲氧苄啶-磺胺甲恶唑组和泼尼松组之间的缓解率差异变小。随访12个月后，尽管83%的患者听力损失达15分贝或更高，但各研究组之间的听力敏感度差异无统计学意义。因此，短期抗菌和抗炎治疗似乎对慢性中耳炎症没有持久影响。
