从神经豆中毒（麦豆病）中吸取的教训：过去的疾病与兵豆（Khesari dal）的未来。
Lessons from neurolathyrism: a disease of the past & the future of Lathyrus sativus (Khesari dal).
机构信息
Department of Biochemistry, Osmania University, Hyderabad, India.
出版信息
Indian J Med Res. 2013;138(1):32-7.
Neurolathyrism is past history in India since Lathyrus sativus (khesari dal) is no longer used as a staple. A consensus has evolved that khesari dal is harmless as part of a normal diet. L-ODAP (β-N-oxalyl-l-α-diamino propionic acid) the neurotoxic amino acid, from this pulse, is detoxified in humans but not in animals but still no laboratory animal is susceptible to it under acceptable feeding regimens. L-ODAP is an activator of protein kinase C and consequential crucial downstream effects such as stabilization of hypoxia inducible factor-1 (HIF-1) could be extremely conducive to humans under a variety of situations. ODAP is gradually finding a place in several patents for this reason. Homoarginine the second amino acid from L. sativus can be a better substrate for endogenous generation of nitric oxide, a crucial signaling molecule associated with the cardiovasculature and control of hypertension. These features could make L. sativus a prized commodity as a functional food for the general cardiovasculature and overcome hypoxic events and is set to change the entire perception of this pulse and neurolathyrism.
神经毒素病在印度已经成为历史，因为黎豆（鹰嘴豆）不再作为主食。人们已经达成共识，认为鹰嘴豆作为正常饮食的一部分是无害的。这种豆类中的神经毒素氨基酸 L-ODAP（β-N-草酰基-L-α-二氨基丙酸）在人体内可以解毒，但在动物体内不行，不过仍然没有实验室动物能够在可接受的喂养方案下对其产生敏感性。L-ODAP 是蛋白激酶 C 的激活剂，由此产生的关键下游效应，如缺氧诱导因子-1（HIF-1）的稳定，在各种情况下对人类可能极为有利。出于这个原因，ODAP 逐渐在多项专利中找到了一席之地。L. sativus 中的第二种氨基酸 homoarginine 可以作为内源性生成一氧化氮的更好底物，一氧化氮是一种与心血管系统相关的关键信号分子，可控制高血压。这些特性使 L. sativus 成为一种有价值的功能性食品，可用于一般心血管系统，并能克服缺氧事件，这将改变人们对这种豆类和神经毒素病的整体认知。
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