Lu Jun-Ti, Deng Ai-Ping, Song Juan, Zhang Li, Luo Jie
Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Department of Clinical Laboratory, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Oncotarget. 2017 Mar 28;8(13):21599-21608. doi: 10.18632/oncotarget.15376.
The association between XRCC1 Arg194Trp polymorphism and glioma risk were inconsistent from published meta-analyses and epidemiological studies. Hence, we performed this updated and cumulative meta-analysis to reappraisal this relationship. PubMed, Embase, CBM (Chinese Biomedical Database), and CNKI (China National Knowledge Internet) databases were comprehensively searched up to August 13, 2016 (updated on December 22, 2016). After study selection and data extraction from eligible studies, the association was evaluated by odds ratios (ORs) and its 95% confidence intervals (95%CIs) using Comprehensive Meta-Analysis software. Finally 16 case-control studies involving 7011 patients and 9519 healthy controls were yielded. The results indicated that XRCC1 Arg194Trp polymorphism was significantly correlated with the increased risk of glioma [Trp vs. Arg: OR = 1.18(1.05-1.34); TrpTrp vs. ArgArg: OR = 1.66(1.31-2.12); ArgTrp vs. ArgArg: OR = 1.34(1.02-1.77); TrpTrp vs. ArgArg+ArgTrp: OR = 1.47(1.26-1.72); TrpTrp+ArgTrp vs. ArgArg: OR = 1.17(1.01-1.35)]. Cumulative analysis showed the results changed from non-significant to significant when new studies accumulated, and sensitivity analysis indicated the results were stable. Subgroup analysis showed the significant association existed in Asians but not in Caucasians. Current evidence indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma, especially in Asians; however, relevant studies involving other ethnic groups are required to validate our findings in further.
已发表的荟萃分析和流行病学研究中，XRCC1基因Arg194Trp多态性与胶质瘤风险之间的关联并不一致。因此，我们进行了这项更新的累积荟萃分析，以重新评估这种关系。全面检索了PubMed、Embase、CBM（中国生物医学数据库）和CNKI（中国知网）数据库，检索截止至2016年8月13日（于2016年12月22日更新）。在从符合条件的研究中进行研究选择和数据提取后，使用综合荟萃分析软件通过比值比（OR）及其95%置信区间（95%CI）评估该关联。最终纳入了16项病例对照研究，涉及7011例患者和9519例健康对照。结果表明，XRCC1基因Arg194Trp多态性与胶质瘤风险增加显著相关[Trp与Arg比较：OR = 1.18(1.05 - 1.34)；TrpTrp与ArgArg比较：OR = 1.66(1.31 - 2.12)；ArgTrp与ArgArg比较：OR = 1.34(1.02 - 1.77)；TrpTrp与ArgArg + ArgTrp比较：OR = 1.47(1.26 - 1.72)；TrpTrp + ArgTrp与ArgArg比较：OR = 1.17(1.01 - 1.35)]。累积分析表明，随着新研究的积累，结果从无显著性变为有显著性，敏感性分析表明结果稳定。亚组分析显示，该显著关联存在于亚洲人中，而在白种人中不存在。当前证据表明，XRCC1基因Arg194Trp多态性与胶质瘤风险增加相关，尤其是在亚洲人中；然而，需要更多涉及其他种族群体的相关研究来进一步验证我们的发现。
