Chen Yong-Ji, Han Ying, Mao Min, Tan Ya-Qin, Leng Wei-Dong, Zeng Xian-Tao
Department of Stomatology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, PR China.
Administrative Office, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
Int J Clin Exp Med. 2015 Feb 15;8(2):2308-16. eCollection 2015.
Multiple studies had focused on the association between interleukin-1 (IL-1) rs1143634 polymorphism and aggressive periodontitis (AgP) susceptibility, but the results remained inconclusive. Therefore, this meta-analysis was conducted to explore its role in the development of AgP. PubMed and Embase databases were searched up to April 15, 2014. After study selection and data extraction form eligible studies, meta-analysis was performed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association. All the analysis was performed using Comprehensive Meta-Analysis software. Finally a total of 25 case-control studies were included. The pooled results showed non-association between AgP susceptibility and IL-1 rs1143634 polymorphism [for T vs. C: OR = 0.99, 95% CI = 0.79-1.23; for TT vs. CC: OR = 1.14, 95% CI = 0.78-1.66; for CT vs. CC: OR = 0.97, 95% CI = 0.70-1.36; for (CT + TT) vs. CC: OR = 1.02, 95% CI = 0.76-1.37; for TT vs. (CT + CC): OR = 1.22, 95% CI = 0.85-1.75]. Subgroup analyses remain did not find any association. No publication bias was detected. Hence, our meta-analysis showed that IL-1β rs1143634 polymorphism is not linked to AgP susceptibility, regardless of ethnicity.
多项研究聚焦于白细胞介素 -1（IL-1）rs1143634 多态性与侵袭性牙周炎（AgP）易感性之间的关联，但结果仍无定论。因此，进行了这项荟萃分析以探讨其在 AgP 发病中的作用。检索了截至 2014 年 4 月 15 日的 PubMed 和 Embase 数据库。在从符合条件的研究中进行研究筛选和数据提取后，进行了荟萃分析。采用比值比（OR）和 95%置信区间（CI）来评估这种关联。所有分析均使用综合荟萃分析软件进行。最终共纳入 25 项病例对照研究。汇总结果显示，AgP 易感性与 IL-1 rs1143634 多态性之间无关联[对于 T 与 C：OR = 0.99，95%CI = 0.79 - 1.23；对于 TT 与 CC：OR = 1.14，95%CI = 0.78 - 1.66；对于 CT 与 CC：OR = 0.97，95%CI = 0.70 - 1.36；对于（CT + TT）与 CC：OR = 1.02，95%CI = 0.76 - 1.37；对于 TT 与（CT + CC）：OR = 1.22，95%CI = 0.85 - 1.75]。亚组分析也未发现任何关联。未检测到发表偏倚。因此，我们的荟萃分析表明，无论种族如何，IL-1β rs1143634 多态性与 AgP 易感性无关。
