Adamec R E
Department of Psychology, Memorial University, St. John's, Newfoundland, Canada.
Biol Psychiatry. 1990 Feb 1;27(3):249-79. doi: 10.1016/0006-3223(90)90001-i.
In this theoretical review, the value of the kindling phenomenon in enhancing our understanding of clinical disorders associated with epilepsy is evaluated. The kindling phenomenon is first described. Kindling is suggested to be a viable model of complex partial seizure (CPS) disorders with secondary generalization. Moreover, it is shown how kindling has been used as a conceptual tool which suggests novel psychiatric therapies. Finally, the value of kindling as a model of psychopathology associated with limbic epilepsy is discussed. It is concluded that studies of the effects of kindling on emotional behavior may offer a model of how limbic seizures in humans increase the vulnerability of patients to external precipitants of psychopathology, including anxiety and depression. Studies of the effects of kindling on dopaminergic function are also reviewed. This line of investigation holds promise for enhancing our understanding of hyperdopaminergic consequences of limbic epilepsy. Furthermore, these studies have created testable hypotheses that may explain the complex relationship between epilepsy and psychosis.
在这篇理论综述中，评估了点燃现象在增进我们对与癫痫相关临床疾病理解方面的价值。首先描述了点燃现象。点燃被认为是伴有继发性全身发作的复杂部分性发作（CPS）疾病的一种可行模型。此外，还展示了点燃如何被用作一种概念工具，从而提出新颖的精神科治疗方法。最后，讨论了点燃作为与边缘叶癫痫相关精神病理学模型的价值。得出的结论是，关于点燃对情绪行为影响的研究可能提供一种模型，说明人类边缘叶癫痫发作如何增加患者对精神病理学外部诱发因素（包括焦虑和抑郁）的易感性。还综述了关于点燃对多巴胺能功能影响的研究。这一研究方向有望增进我们对边缘叶癫痫的高多巴胺能后果的理解。此外，这些研究提出了可检验的假设，可能解释癫痫与精神病之间的复杂关系。
