理解癫痫发作与精神病之间拮抗作用的模型。

Models for understanding the antagonism between seizures and psychosis.

Pollock D C

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):483-504. doi: 10.1016/0278-5846(87)90017-0.

Abstract

The relationship between seizures and psychosis is reviewed using incidence and association studies, and experimental models of kindling and behavioral sensitization. 2. While there are conflicting data on the association of psychopathology with epilepsy, studies illustrating the antagonism between seizures and psychosis are examined along with the phenomenon of "Forced Normalization". 3. Electrical kindling of the amygdala provides a model of temporal lobe epilepsy while pharmacologic kindling/behavioral sensitization or dopaminergic kindling provides a model for psychosis. 4. A model explaining both the etiology and the reciprocal nature of seizures and psychosis in temporal lobe epilepsy is developed. Preictal and interictal spikes kindle both proconvulsive and inhibitory pathways of seizure expression and behaviorally relevant limbic systems. That system currently expressive, either seizure or psychosis, while under high synchronous drive would tend to fail allowing for the emergence of the opposing system.

摘要

运用发病率和关联性研究、点燃模型及行为敏化实验模型，对癫痫发作与精神病之间的关系进行了综述。2. 虽然关于精神病理学与癫痫之间的关联存在相互矛盾的数据，但阐述癫痫发作与精神病之间拮抗作用的研究以及“强制正常化”现象也得到了审视。3. 杏仁核的电点燃提供了颞叶癫痫模型，而药理学点燃/行为敏化或多巴胺能点燃则提供了精神病模型。4. 构建了一个解释颞叶癫痫中癫痫发作和精神病的病因及其相互关系的模型。发作前和发作间期的棘波会点燃癫痫发作表达的促惊厥和抑制通路以及与行为相关的边缘系统。当前表现为癫痫发作或精神病的那个系统，在高度同步驱动下往往会失效，从而使相对的系统得以出现。