1 Department of Psychology & Neuroscience, Regis University, Denver, Colorado.
J Int Neuropsychol Soc. 2013 Oct;19(9):995-1008. doi: 10.1017/S1355617713000957.
The primary purpose of this study was to test the hypothesis that multiple sclerosis (MS) patients have impaired acquisition rather than a retrieval deficit. Verbal memory impairment in MS was examined in 53 relapsing-remitting MS patients and 31 healthy controls (HC), and in a meta-analysis of studies that examined memory functioning in MS with list-learning tasks. The MS group demonstrated significantly lower acquisition and delayed recall performance than the HC group, and the meta-analysis revealed that the largest effect sizes were obtained for acquisition measures relative to delayed recall and recognition. Our data argue against a retrieval deficit as the sole explanation for verbal memory impairment in MS, and make a consistent case for the position that deficient acquisition contributes to the memory dysfunction of MS patients. Deficient acquisition may result from demyelination in relevant white matter tracts that reduces encoding efficiency as a result of impaired speed of information processing.
本研究的主要目的是验证假设，即多发性硬化症 (MS) 患者存在获取障碍而非检索缺陷。在 53 例复发缓解型 MS 患者和 31 例健康对照者（HC）中，以及在对使用列表学习任务检查 MS 患者记忆功能的研究进行的荟萃分析中，检查了 MS 患者的言语记忆障碍。MS 组的获取和延迟回忆表现明显低于 HC 组，荟萃分析显示，与延迟回忆和识别相比，获取测量的效应量最大。我们的数据反对将检索缺陷作为 MS 患者言语记忆障碍的唯一解释，并一致认为，获取不足导致 MS 患者的记忆功能障碍。获取不足可能是由于相关白质束脱髓鞘，导致信息处理速度受损，从而降低编码效率。
