朊病毒化学生物学：走向治疗之路？

Prion chemical biology: on the road to therapeutics?

机构信息

Dainton Building, Department of Chemistry, University of Sheffield, Brookhill, Sheffield S3 7HF, UK.

出版信息

Curr Top Med Chem. 2013;13(19):2441-64. doi: 10.2174/15680266113136660172.

Abstract

Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.

摘要

朊病毒病，也称为传染性海绵状脑病（TSEs），是一种具有传染性和致命性的神经退行性疾病。到目前为止，还没有具有临床疗效的治疗方法。本文综述了主要类别的小分子抗朊病毒化合物的发现，希望能为针对朊病毒和其他神经退行性疾病的药物发现指明未来的方向。