Department of Neurology and Epileptology, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Hoppe-Seyler-Str,3, Tuebingen 72076, Germany.
BMC Neurol. 2013 Sep 23;13:124. doi: 10.1186/1471-2377-13-124.
Itch is a frequent complaint reported by patients and is usually ascribed to dermatological or metabolic causes. In neurological disorders, however, it is a very unusual symptom and thus its neurological aetiology is likely to be overlooked. There are only very few reports about permanent itch related to lesions of the central nervous system. To our knowledge we report the first case of episodic itch associated with a central nervous lesion.
A 74-year-old female suffered from long-standing episodes of itch of the dermatomes C2 to C6 on the right side that was refractory to any treatment. On occurrence it propagated in a proximal to distal fashion. Between the episodes the patient was asymptomatic. MRI of the cervical spine uncovered a spinal glioma that matched the location of the symptoms. Treatment with gabapentin led to a prompt reduction of the symptoms.
Patients with intractable pruritus and dermatomal presentation ought to undergo neurological examination and spinal cord imaging. Thus, ongoing frustrating and sometimes even harmful treatment trials could be avoided.
瘙痒是患者常报告的一种常见症状,通常归因于皮肤科或代谢原因。然而,在神经系统疾病中,它是一种非常不常见的症状,因此其神经病因很可能被忽视。关于与中枢神经系统损伤相关的持续性瘙痒,仅有极少数的报道。据我们所知,我们报告了首例与中枢神经系统病变相关的阵发性瘙痒病例。
一名 74 岁女性长期右侧 C2 至 C6 皮节的瘙痒发作,对任何治疗均无反应。发作时,瘙痒呈向心性传播。发作之间,患者无症状。颈椎 MRI 发现脊髓内神经胶质瘤,与症状部位相吻合。加巴喷丁治疗迅速减轻了症状。
对于难治性瘙痒和皮节表现的患者,应进行神经检查和脊髓成像。因此,可以避免正在进行的令人沮丧且有时甚至有害的治疗试验。