Nikitovic Dragana, Papoutsidakis Antonis, Karamanos Nikos K, Tzanakakis George N
Department of Anatomy-Histology-Embryology, Medical School, University of Crete, Heraklion 71003, Greece.
Department of Anatomy-Histology-Embryology, Medical School, University of Crete, Heraklion 71003, Greece.
Matrix Biol. 2014 Apr;35:206-14. doi: 10.1016/j.matbio.2013.09.003. Epub 2013 Sep 21.
The consecutive steps of tumor growth, local invasion, intravasation, extravasation and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. Lumican, a class II small leucine-rich proteoglycans (SLRP) has been designated key roles both in extracellular matrix (ECM) organization and as an important modulator of biological functions. This review will critically discuss lumicans' roles in tumor development and progression. We will especially focus on correlating lumicans' expression and distribution in tumor tissues with: (1) the organization of the tumor matrices; (2) tumor cell signaling and functions; (3) tumor cell-matrix interface; (4) tumor angiogenesis; and (5) lumicans' potential roles in tumor-associated inflammatory response. Present knowledge of lumicans' biology provides a fundamental platform upon which to build and deepen our understanding of lumican function in tumorigenesis in order to be able to design credible anti-tumor approaches.
肿瘤生长、局部侵袭、血管内渗、血管外渗以及对解剖学上远处部位的侵袭等连续步骤必然是通过肿瘤细胞与其微环境的特定相互作用来实现的。核纤蛋白是一种II类富含亮氨酸的小分子蛋白聚糖（SLRP），在细胞外基质（ECM）组织以及作为生物学功能的重要调节因子方面都发挥着关键作用。本综述将批判性地讨论核纤蛋白在肿瘤发生和发展中的作用。我们将特别关注肿瘤组织中核纤蛋白的表达和分布与以下方面的相关性：（1）肿瘤基质的组织；（2）肿瘤细胞信号传导和功能；（3）肿瘤细胞-基质界面；（4）肿瘤血管生成；以及（5）核纤蛋白在肿瘤相关炎症反应中的潜在作用。目前对核纤蛋白生物学的认识为构建和深化我们对核纤蛋白在肿瘤发生中的功能理解提供了一个基本平台，以便能够设计出可靠的抗肿瘤方法。
