State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Genomics Proteomics Bioinformatics. 2013 Oct;11(5):294-8. doi: 10.1016/j.gpb.2013.09.002. Epub 2013 Sep 21.
Induced pluripotent stem cells (iPSCs) are generated by ectopic expression of defined transcription factors in somatic cells. They can undergo unlimited self-renewal and maintain the embryonic stem cells (ESCs)-like ability to differentiate into all three germ layers. iPSCs can potentially provide unlimited autologous cells for therapy and therefore hold great promise for regenerative medicine. Here we reviewed the recent advances in iPSC studies on disease modeling and clinical treatment as well as challenges correlated with clinical development of iPSCs, like tumorigenicity, immunogenicity and genomic instability.
诱导多能干细胞（iPSCs）是通过在体细胞中异位表达特定转录因子产生的。它们可以进行无限的自我更新，并保持胚胎干细胞（ESCs）样的能力，分化为所有三个胚层。iPSCs 有可能为治疗提供无限的自体细胞，因此为再生医学带来了巨大的希望。在这里，我们回顾了 iPSC 在疾病建模和临床治疗方面的最新进展，以及与 iPSC 临床开发相关的挑战，如致瘤性、免疫原性和基因组不稳定性。
