Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
Chem Commun (Camb). 2013 Nov 11;49(87):10236-8. doi: 10.1039/c3cc45911j.
A regioselective Heck reaction of aliphatic olefins and aryl bromides is realized at internal carbons of olefins. Methanol solvent promoted halide ionization from neutral arylpalladium halide complexes via hydrogen bonding, so as to create cationic aryl-Pd species for regioselective olefin insertion.
实现了脂肪族烯烃和芳基溴化物的区域选择性 Heck 反应，反应发生在烯烃的内部碳原子上。甲醇溶剂通过氢键促进中性芳基钯卤化物配合物中的卤化物离解，从而形成阳离子芳基-Pd 物种，以实现区域选择性烯烃插入。
