Hall J M, Huey B, Morrow J, Newman B, Lee M, Jones E, Carter C, Buehring G C, King M C
School of Public Health, University of California, Berkeley 94720.
Genomics. 1990 Jan;6(1):188-91. doi: 10.1016/0888-7543(90)90466-8.
The suggestion that inherited rare alleles at the HRAS oncogene locus might be associated with susceptibility to breast cancer led us to test linkage of HRAS and the neighboring region of 11p15 to breast cancer susceptibility in 12 high-risk families. Linkage could be excluded within 17 cM of HRAS; the lod score for close linkage to HRAS was -19.9. In addition, rare HRAS alleles segregated independently of breast cancer in 8 families in which both occurred. Among unrelated breast cancer patients not selected for family history, rare HRAS alleles were slightly, but not significantly, more frequent than among controls (0.11 vs 0.04, P = 0.11). The HRAS region of 11p is not the site of a primary alteration leading to breast cancer.
HRAS癌基因位点的遗传性罕见等位基因可能与乳腺癌易感性相关这一观点，促使我们在12个高危家族中检测HRAS及11p15邻近区域与乳腺癌易感性的连锁关系。在HRAS的17厘摩范围内可排除连锁关系；与HRAS紧密连锁的对数优势比为-19.9。此外，在8个同时存在罕见HRAS等位基因和乳腺癌的家族中，罕见HRAS等位基因与乳腺癌独立分离。在未根据家族史选择的非相关乳腺癌患者中，罕见HRAS等位基因的频率略高于对照组，但无显著差异（0.11对0.04，P = 0.11）。11p的HRAS区域不是导致乳腺癌的主要改变位点。
