Institute of Biomaterials, Friedrich-Alexander Universität Erlangen Nürnberg, Cauerstraße 6, 91058 Erlangen, Germany.
Adv Mater. 2013 Aug 7;25(29):4049-57. doi: 10.1002/adma.201301227.
Which mechanisms mediate cell attachment to biomaterials? What role does the surface charge or wettability play on cell-material anchorage? What are the currently investigated strategies to modify cell-matrix adherence spatiotemporally? Considering the development of scaffolds made of biocompatible materials to temporarily replace the structure and/or function of the extracellular matrix, focus is given to the analysis of the specific (i.e., cell adhesive peptide sequences) and unspecific (i.e., surface charge, wettability) mechanisms mediating cell-matrix interactions. Furthermore, because natural tissue regeneration is characterized by the dynamic attachment/detachment of different cell populations, the design of advanced scaffolds for tissue engineering, based in the spatiotemporal tuning of cell-matrix anchorage is discussed.
哪些机制介导细胞与生物材料的附着？表面电荷或润湿性在细胞与材料附着中的作用是什么？目前有哪些研究策略可以在时空上修饰细胞-基质的附着？考虑到开发由生物相容性材料制成的支架来暂时替代细胞外基质的结构和/或功能，重点分析了介导细胞-基质相互作用的特定（即细胞黏附肽序列）和非特定（即表面电荷、润湿性）机制。此外，由于天然组织再生的特点是不同细胞群体的动态附着/脱附，因此讨论了基于细胞-基质附着的时空调节设计用于组织工程的先进支架。
