Leone Angelique, Dark Michael, Kondo Hirotaka, Rotstein David S, Kiupel Matti, Walsh Michael T, Erlacher-Reid Claire, Gordon Nadia, Conway Julia A
Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32612, USA.
J Zoo Wildl Med. 2013 Sep;44(3):744-8. doi: 10.1638/2012-0147R.1.
An adult male pygmy sperm whale (Kogia breviceps) was stranded within a tidal pool on Fernandina Beach on the north Florida Atlantic coast (USA) and expired soon after discovery. Necropsy findings included a small intestinal mass markedly expanding the intestinal wall and partially obstructing the lumen. This finding likely led to the malnutrition and ultimately the stranding of this whale. The differential diagnoses for the mass based on gross evaluation included a duodenal adenocarcinoma, leiomyoma/sarcoma, gastrointestinal stroma tumor, and benign/malignant peripheral nerve sheath tumor, previously referred to as neurofibromas or schwannomas. The mass was presumptively diagnosed as a leiomyosarcoma via routine histopathology and confirmed by immunoreactivity for desmin and smooth actin (SMA). KIT, a gene name for CD 117, was negative, excluding a gastrointestinal stromal tumor (GIST). Leiomyosarcomas have been reported within numerous wild and domestic species, although this is the first reported case of any neoplasm in a pygmy sperm whale (K. breviceps).
一头成年雄性侏儒抹香鲸（Kogia breviceps）在美国佛罗里达州大西洋海岸北部的费南迪纳海滩的一个潮汐池中搁浅，被发现后不久死亡。尸检结果显示，小肠有一个肿块，明显使肠壁扩张并部分阻塞肠腔。这一发现可能导致了这头鲸鱼营养不良，最终使其搁浅。基于大体评估，该肿块的鉴别诊断包括十二指肠腺癌、平滑肌瘤/肉瘤、胃肠道间质瘤以及良性/恶性外周神经鞘瘤（以前称为神经纤维瘤或施万细胞瘤）。通过常规组织病理学初步诊断该肿块为平滑肌肉瘤，并通过结蛋白和平滑肌肌动蛋白（SMA）免疫反应性得到证实。KIT（CD 117的基因名称）为阴性，排除了胃肠道间质瘤（GIST）。平滑肌肉瘤已在许多野生和家养物种中被报道，尽管这是首次报道侏儒抹香鲸（K. breviceps）发生任何肿瘤的病例。
