Igarashi Toru, Mori Katsuya, Inoue Kei, Suzuki Takeshi, Morisaki Hiroshi
Department of Anesthesiology, Keio University School of Medicine, Tokyo 160-8582.
Masui. 2013 Sep;62(9):1097-105.
Regional anesthesia has been widely applied as an excellent method for perioperative analgesia. Recent studies suggested that regional anesthesia is a promising approach to minimize the risk of surgical site infection and postoperative cancer recurrence, subsequently providing the benefits to the long-term outcome. In particular, it is of great interest that regional anesthesia might be able to reduce cancer recurrence. In cancer patients, innate immunity against cancer could be depressed, resulting in the predisposition to evoke metastasis. Besides, during the perioperative periods, tumor immunity is significantly depressed due to surgical pain, activation of sympathetic nervous system, inflammatory responses, and others. In this review article, we discuss the tumor immunity during the perioperative period, with focus on the alterations of tumor immunity and regional anesthesia.
区域麻醉作为一种出色的围手术期镇痛方法已被广泛应用。最近的研究表明，区域麻醉是一种很有前景的方法，可将手术部位感染和术后癌症复发的风险降至最低，从而为长期预后带来益处。特别值得关注的是，区域麻醉可能能够降低癌症复发率。在癌症患者中，针对癌症的先天免疫可能会受到抑制，从而导致易发生转移。此外，在围手术期，由于手术疼痛、交感神经系统激活、炎症反应等因素，肿瘤免疫会显著降低。在这篇综述文章中，我们将讨论围手术期的肿瘤免疫，重点关注肿瘤免疫的变化和区域麻醉。
