Department of Physiological Sciences, Piracicaba Dental School, University of Campinas - UNICAMP, P,O, Box 52, 13414-018 Piracicaba, SP, Brazil.
BMC Complement Altern Med. 2013 Sep 24;13:235. doi: 10.1186/1472-6882-13-235.
Guava pomace is an example of the processing waste generated after the manufacturing process from the juice industry that could be a source of bioactives. Thus, the present investigation was carried out in order to evaluate the anti-inflammatory and antinociceptive potential and determinate the main phenolic compounds of a guava pomace extract (GPE).
The anti-inflammatory activity was evaluated by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models. Acetic acid-induced abdominal writhing and formalin test were performed to investigate the antinociceptive effects. In addition, the content of total phenolic and of individual phenolic compounds was determined by GC/MS.
GPE showed anti-inflammatory activity by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models (p < 0.05). GPE also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test (p < 0.05). The total phenolic value was 3.40 ± 0.09 mg GAE/g and epicatechin, quercetin, myricetin, isovanilic and gallic acids were identified by GC/MS analysis.
The presence of bioactive phenolic compounds as well as important effects demonstrated in animal models suggest that guava pomace could be an interesting source of anti-inflammatory and analgesic substances.
番石榴渣是果汁工业制造过程中产生的加工废物的一个例子，它可能是生物活性物质的来源。因此，本研究旨在评估番石榴渣提取物（GPE）的抗炎和镇痛潜力，并确定其主要的酚类化合物。
通过角叉菜胶、葡聚糖、血清素、组胺诱导的足肿胀和腹腔中性粒细胞迁移模型评估抗炎活性。通过醋酸诱导的腹部扭曲和福尔马林试验研究镇痛作用。此外，通过 GC/MS 测定总酚和各酚类化合物的含量。
GPE 在角叉菜胶、葡聚糖、血清素、组胺诱导的足肿胀和腹腔中性粒细胞迁移模型中表现出抗炎活性（p<0.05）。GPE 在醋酸诱导的腹部扭曲和福尔马林试验中也表现出镇痛活性（p<0.05）。总酚值为 3.40±0.09mgGAE/g，通过 GC/MS 分析鉴定出表儿茶素、槲皮素、杨梅素、异香草酸和没食子酸。
存在生物活性酚类化合物以及在动物模型中表现出的重要作用表明，番石榴渣可能是抗炎和镇痛物质的一个有趣来源。
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