使用HLA转染细胞分析抗原呈递。 - Suppr

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Analysis of antigen presentation using HLA transfectants.

作者信息

Altmann D M, Wilkinson D, Ikeda H, Trowsdale J

机构信息

Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, UK.

出版信息

Immunol Res. 1990;9(1):57-68. doi: 10.1007/BF02918479.

DOI:10.1007/BF02918479

PMID:2406352

Abstract

摘要

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本文引用的文献

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.分泌针对小鼠H-2和Ia抗原的单克隆抗体的杂交瘤细胞系。

J Immunol. 1980 Feb;124(2):533-40.

Two populations of Ia-like molecules on a human B cell line.人类B细胞系上的两类Ia样分子。

J Immunol. 1980 Jul;125(1):293-9.

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.免疫干扰素可激活人类内皮细胞和真皮成纤维细胞中的多个II类主要组织相容性复合体基因以及相关的恒定链基因。

Proc Natl Acad Sci U S A. 1984 Aug;81(15):4917-21. doi: 10.1073/pnas.81.15.4917.

The mechanism of antigen presentation by endothelial cells.

Immunobiology. 1984 Dec;168(3-5):453-69. doi: 10.1016/S0171-2985(84)80130-8.

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells.表达异常MHC II类决定簇的上皮细胞可将抗原呈递给克隆化的人T细胞。

Nature. 1984;312(5995):639-41. doi: 10.1038/312639a0.

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.H-2 限制性 T 细胞的抗原识别。I. 无细胞抗原处理。

J Exp Med. 1983 Aug 1;158(2):303-16. doi: 10.1084/jem.158.2.303.

HLA antigen expression at the single cell level on a K562 X B cell hybrid: an analysis with monoclonal antibodies using bacterial binding assays.

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Monoclonal and xenoantibodies specific for HLA-DR inhibit primary responses to HLA-D but fail to inhibit secondary proliferative (PLT) responses to allogeneic cells.针对HLA - DR的单克隆抗体和异种抗体可抑制对HLA - D的初次反应，但无法抑制对异基因细胞的二次增殖反应（PLT反应）。

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Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity.异常HLA - DR表达和抗原呈递在内分泌自身免疫诱导中的作用。

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Human cytotoxic T-lymphocyte recognition of an HLA-A3 gene product expressed on murine L cells: the only human gene product required on the target cells for lysis is the class I heavy chain.人细胞毒性T淋巴细胞对在鼠L细胞上表达的HLA - A3基因产物的识别：靶细胞上进行裂解所需的唯一人类基因产物是I类重链。

Proc Natl Acad Sci U S A. 1985 Jul;82(13):4490-4. doi: 10.1073/pnas.82.13.4490.

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