Université de Strasbourg ICube, UNISTRA-CNRS, 2 Rue Boussingault, 67000 Strasbourg, France.
Université de Strasbourg ICube, UNISTRA-CNRS, 2 Rue Boussingault, 67000 Strasbourg, France.
J Mech Behav Biomed Mater. 2014 May;33:24-42. doi: 10.1016/j.jmbbm.2013.08.022. Epub 2013 Sep 4.
This paper proposes the implementation of fractional anisotropy and axonal fiber orientation from diffusion tensor imaging (DTI) of 12 healthy patients into an existing human FE head model to develop a more realistic brain model with advanced constitutive laws. Further, the brain behavior was validated in terms of brain strain against experimental data published by Hardy et al. (2001, 2007) and for brain pressure against Nahum et al. (1977) experimental impacts. A reasonable agreement was observed between the simulation and experimental data. Results showed the feasibility of integrating axonal direction information into FE analysis and established the context of computation of axonal elongation in case of head trauma.
本文提出了从 12 名健康患者的弥散张量成像（DTI）中提取分数各向异性和轴突纤维方向，并将其应用于现有的人体有限元（FE）头部模型中，以开发具有先进本构定律的更逼真的大脑模型。此外，还根据 Hardy 等人（2001 年，2007 年）发表的实验数据和 Nahum 等人（1977 年）的实验撞击数据，对大脑应变进行了脑行为验证。在模拟和实验数据之间观察到了合理的一致性。结果表明，将轴突方向信息集成到 FE 分析中的可行性，并为头部创伤时轴突伸长的计算建立了计算环境。
