短暂性脑缺血发作患者的局部一致性异常：一项静息态功能磁共振成像研究。

Regional homogeneity abnormalities in patients with transient ischaemic attack: a resting-state fMRI study.

作者信息

Guo Jian, Chen Ning, Li Rong, Wu Qizhu, Chen Huafu, Gong Qiyong, He Li

机构信息

Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, PR China.

Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610041, PR China.

出版信息

Clin Neurophysiol. 2014 Mar;125(3):520-5. doi: 10.1016/j.clinph.2013.08.010. Epub 2013 Sep 21.

DOI:10.1016/j.clinph.2013.08.010

Abstract

OBJECTIVE

To investigate regional activity abnormalities in the resting state in patients with transient ischaemic attack (TIA) using a regional homogeneity (ReHo) method combined with functional magnetic resonance imaging (fMRI) and to examine the relationship between regional activity abnormalities and clinical variables.

METHODS

Resting-state fMRI was conducted in 21 patients with right-sided TIA and in 21 healthy volunteers. The ReHo was calculated to assess the strength of the local signal synchrony and was compared between the two groups.

RESULTS

Compared with the controls, the TIA patients exhibited a decreased ReHo in the right dorsolateral prefrontal cortex (dlPFC), the right inferior prefrontal cortex (iPFC), the right ventral anterior cingulate cortex (vACC) and the right dorsal posterior cingulate cortex (dPCC). In addition, the mean ReHo values in the right dlPFC and the right iPFC were significantly correlated with the Montreal Cognitive Assessment (MoCA) in TIA patients.

CONCLUSIONS

Neural activities in the resting state are changed in TIA patients even without visible ischaemic lesions on conventional MRI. The positive correlation between the ReHo of resting-state fMRI and cognition suggests that ReHo could be a promising tool to observe the neurobiological consequences of TIA.

SIGNIFICANCE

The present study revealed abnormal local synchronisation of spontaneous neural activities in patients with TIA.

摘要

目的

采用局部一致性（ReHo）方法结合功能磁共振成像（fMRI）研究短暂性脑缺血发作（TIA）患者静息状态下的局部活动异常，并探讨局部活动异常与临床变量之间的关系。

方法

对21例右侧TIA患者和21名健康志愿者进行静息态fMRI检查。计算ReHo以评估局部信号同步性强度，并在两组之间进行比较。

结果

与对照组相比，TIA患者右侧背外侧前额叶皮质（dlPFC）、右侧前额叶下部皮质（iPFC）、右侧腹侧前扣带回皮质（vACC）和右侧背侧后扣带回皮质（dPCC）的ReHo降低。此外，TIA患者右侧dlPFC和右侧iPFC的平均ReHo值与蒙特利尔认知评估量表（MoCA）显著相关。

结论

即使在传统MRI上没有可见缺血性病变，TIA患者静息状态下的神经活动也会发生改变。静息态fMRI的ReHo与认知之间的正相关表明，ReHo可能是观察TIA神经生物学后果的一种有前景的工具。

意义

本研究揭示了TIA患者自发神经活动的局部同步异常。