Beijing Key Laboratory of Learning and Cognition, School of Education, Capital Normal University, Beijing 100048, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 625014, China.
J Affect Disord. 2018 Aug 1;235:229-235. doi: 10.1016/j.jad.2018.04.061. Epub 2018 Apr 7.
Cognitive vulnerability to depression (CVD) is a high risk for depressive disorder. Recent studies focus on individuals with CVD to determine the neural basis of major depressive disorder (MDD) neuropathology. However, whether CVD showed specific or similar brain functional activity and connectivity patterns, compared to MDD, remain largely unknown.
Here, using resting-state functional magnetic resonance imaging in subjects with CVD, healthy controls (HC) and MDD, regional homogeneity (ReHo) and resting-state functional connectivity (R-FC) analyses were conducted to assess local synchronization and changes in functional connectivity patterns.
Significant ReHo differences were found in right posterior lobe of cerebellum (PLC), left lingual gyrus (LG) and precuneus. Compared to HC, CVD subjects showed increased ReHo in the PLC, which was similar to the difference found between MDD and HC. Compared to MDD patients, CVD subjects showed decreased ReHo in PLC, LG, and precuneus. R-FC analyses found increased functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex in CVD compared to both HC and MDD. Moreover, Regional mean ReHo values were positively correlated with Center for Epidemiologic Studies Depression Scale scores.
These analyses revealed that PLC and functional connections between LG and left inferior parietal lobule, posterior cingulate cortex, and dorsolateral prefrontal cortex may be a potential marker for CVD.
对抑郁症的认知脆弱性（CVD）是抑郁障碍的高风险因素。最近的研究集中在有 CVD 的个体上，以确定重度抑郁症（MDD）神经病理学的神经基础。然而，与 MDD 相比，CVD 是否表现出特定或相似的大脑功能活动和连通模式在很大程度上仍不清楚。
在这里，我们使用 CVD 患者、健康对照（HC）和 MDD 患者的静息态功能磁共振成像，进行局部一致性（ReHo）和静息态功能连接（R-FC）分析，以评估局部同步和功能连接模式的变化。
在小脑右后叶（PLC）、左舌回（LG）和楔前叶发现了显著的 ReHo 差异。与 HC 相比，CVD 患者的 PLC 中 ReHo 增加，与 MDD 与 HC 之间的差异相似。与 MDD 患者相比，CVD 患者的 PLC、LG 和楔前叶的 ReHo 降低。R-FC 分析发现，与 HC 和 MDD 相比，CVD 患者的 LG 与左顶下小叶、后扣带回和背外侧前额叶之间的功能连接增加。此外，区域平均 ReHo 值与流行病学研究抑郁量表评分呈正相关。
这些分析表明，PLC 以及 LG 与左顶下小叶、后扣带回和背外侧前额叶之间的功能连接可能是 CVD 的潜在标志物。
