Pereira H A, Spitznagel J K, Pohl J, Wilson D E, Morgan J, Palings I, Larrick J W
Dept. of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.
Life Sci. 1990;46(3):189-96. doi: 10.1016/0024-3205(90)90104-y.
We have previously shown that a major granule-associated cationic protein CAP 37 (Mr = 37 kD) derived from human PMN is a monocyte-specific chemoattractant. The N-terminal amino acid sequence of this novel chemotactic protein shares significant homology with a number of inflammatory molecules with protease activity including elastase and cathepsin G. However, a critical substitution of a serine for a histidine at position 41, results in its lack of serine protease activity.
我们先前已表明，一种源自人中性粒细胞的主要颗粒相关阳离子蛋白CAP 37（分子量 = 37 kD）是一种单核细胞特异性趋化因子。这种新型趋化蛋白的N端氨基酸序列与许多具有蛋白酶活性的炎症分子（包括弹性蛋白酶和组织蛋白酶G）具有显著同源性。然而，在第41位氨基酸处丝氨酸对组氨酸的关键取代，导致其缺乏丝氨酸蛋白酶活性。
