Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy.
Endocrine. 2014 Apr;45(3):362-4. doi: 10.1007/s12020-013-0056-2. Epub 2013 Sep 26.
Metabolic syndrome has become a major public health problem worldwide and represents a common clinical condition in countries with a high incidence of obesity and western dietary patterns. Metabolic syndrome associates with common cancers at many sites, including liver, colorectal, and bladder cancers in men, and endometrial, pancreatic, breast post-menopausal, and colorectal cancers in women. However, the role played by each single component of the syndrome on cancer risk is still unclear. For endometrial cancer, obesity and/or high circumference waist explain all the risk associated with the full metabolic syndrome, while for post-menopausal breast cancer, the risk conveyed by metabolic syndrome appears to be greater than its parts, as no single component explains the full risk associated with the syndrome. Future research should cover other avenues in order to elucidate the complexity of biological processes linking metabolic syndrome and cancer.
代谢综合征已成为全球主要的公共卫生问题，在肥胖症和西方饮食模式高发的国家，它是一种常见的临床病症。代谢综合征与许多部位的常见癌症相关，包括男性的肝癌、结直肠癌和膀胱癌，以及女性的子宫内膜癌、胰腺癌、绝经后乳腺癌和结直肠癌。然而，代谢综合征的各个单一成分在癌症风险中的作用仍不清楚。对于子宫内膜癌，肥胖症和/或高腰围解释了与完整代谢综合征相关的所有风险，而对于绝经后乳腺癌，代谢综合征所带来的风险似乎大于其各个成分，因为没有单一成分能够解释与该综合征相关的全部风险。未来的研究应该涵盖其他方面，以阐明将代谢综合征与癌症联系起来的复杂的生物学过程。
