Esancy J F, Freeman H S, Claxton L D
Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh 27695-8302.
Mutat Res. 1990 Jan;238(1):1-22. doi: 10.1016/0165-1110(90)90036-b.
15 aminoazobenzene dyes and 7 of their reductive-cleavage products were examined in the Salmonella/microsome assay with strains TA98, TA100, TA1535, TA1537 and TA1538. Dyes tested included 5 derivatives of 4-aminoazobenzene with different alkoxy substituents (-OCH3, -OCH2CH3, -OCH2CH2 CH3, -OCH2CH2CH2CH3 or -OCH2CH2OH) in the 8-position as well as the corresponding derivatives of 4-[(4-aminophenyl)azo]-N,N-diethylaniline and 4-[(4-aminophenyl)azo]-N,N-bis(2-hydroxyethyl)aniline. In general, as the size of the substituent ortho to the primary amino group of the dyes was increased, the mutagenicity decreased. A similar trend was observed for the reductive-cleavage products. The results from the latter aspect of this study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products.
在沙门氏菌/微粒体试验中，使用TA98、TA100、TA1535、TA1537和TA1538菌株检测了15种氨基偶氮苯染料及其7种还原裂解产物。所测试的染料包括8位带有不同烷氧基取代基（-OCH3、-OCH2CH3、-OCH2CH2CH3、-OCH2CH2CH2CH3或-OCH2CH2OH）的4-氨基偶氮苯的5种衍生物，以及4-[(4-氨基苯基)偶氮]-N,N-二乙苯胺和4-[(4-氨基苯基)偶氮]-N,N-双(2-羟乙基)苯胺的相应衍生物。一般来说，随着染料伯氨基邻位取代基尺寸的增加，致突变性降低。还原裂解产物也观察到类似趋势。本研究这后一方面的结果表明，氨基偶氮苯染料的致突变性不能仅由其还原裂解产物的性质来解释。
