Rauchs Géraldine, Piolino Pascale, Bertran Françoise, de La Sayette Vincent, Viader Fausto, Eustache Francis, Desgranges Béatrice
U1077, INSERM , Caen , France ; UMR-S1077, Université de Caen Basse-Normandie , Caen , France ; UMR-S1077, Ecole Pratique des Hautes Etudes , Caen , France ; U1077, Centre Hospitalier Universitaire , Caen , France.
Front Behav Neurosci. 2013 Sep 18;7:114. doi: 10.3389/fnbeh.2013.00114. eCollection 2013.
Autobiographical memory is commonly impaired in Alzheimer's disease (AD). However, little is known about the very recent past which is though highly important in daily life adaptation. In addition, the impact of sleep disturbances, also frequently reported in AD, on the consolidation, and retrieval of autobiographical memories remains to be assessed. Using an adaptation of the TEMPau task, we investigated the neural substrates of autobiographical memory for recent events and the potential relationship with sleep in 14 patients with mild AD. On day 1, autobiographical memory was explored across three periods: remote (18-30 years), the last 2 years and the last month. After testing, sleep was recorded using polysomnography. The next day, AD patients benefited a resting-state (18)FDG-PET scan and a second exploration of autobiographical memory, focusing on the very recent past (today and yesterday). Total recall and episodic recall scores were obtained. In addition, for all events recalled, Remember responses justified by specific factual, spatial, and temporal details were measured using the Remember/Know paradigm. Retrieval of autobiographical memories was impaired in AD, but recall of young adulthood and very recent events was relatively better compared to the two intermediate periods. Recall of recent events (experienced the day and the day preceding the assessment) was correlated with brain glucose consumption in the precuneus and retrosplenial cortex, the calcarine region, the angular gyrus, and lateral temporal areas. AD patients also provided more Justified Remember responses for events experienced the previous-day than for those experienced the day of the assessment. Moreover, Justified Remember responses obtained for events experienced before sleep were positively correlated with the amount of slow-wave sleep. These data provide the first evidence of an association between the ability to retrieve recent autobiographical memories and sleep in mild AD patients.
自传体记忆在阿尔茨海默病（AD）中通常会受损。然而，对于日常生活适应中非常重要的最近过去的情况却知之甚少。此外，睡眠障碍在AD中也经常被报道，但其对自传体记忆巩固和提取的影响仍有待评估。我们采用TEMPau任务的改编版，对14例轻度AD患者近期事件的自传体记忆神经基质及其与睡眠的潜在关系进行了研究。在第1天，我们在三个时间段探究了自传体记忆：远期（18 - 30年）、过去2年和过去1个月。测试后，使用多导睡眠图记录睡眠情况。第二天，AD患者接受静息态（18）FDG - PET扫描，并再次探究自传体记忆，重点关注最近的过去（今天和昨天）。获得了总回忆和情景回忆分数。此外，对于所有回忆起的事件，使用“记得/知道”范式测量由特定事实、空间和时间细节证明的“记得”反应。AD患者的自传体记忆提取受损，但与两个中间时间段相比，对青年期和最近事件的回忆相对较好。对近期事件（评估当天及前一天经历的）的回忆与楔前叶、压后皮质、距状区、角回和颞叶外侧区域的脑葡萄糖消耗相关。AD患者对前一天经历的事件提供的“有依据的记得”反应也比对评估当天经历的事件更多。此外，睡眠前经历的事件获得的“有依据的记得”反应与慢波睡眠量呈正相关。这些数据首次证明了轻度AD患者近期自传体记忆提取能力与睡眠之间存在关联。
