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微流控法制备稳定充气体微胶囊用于声对比增强。

Microfluidic fabrication of stable gas-filled microcapsules for acoustic contrast enhancement.

机构信息

School of Engineering and Applied Sciences and Department of Physics, Harvard University , 29 Oxford Street, Cambridge, Massachusetts 02138, United States.

出版信息

Langmuir. 2013 Oct 8;29(40):12352-7. doi: 10.1021/la402598p. Epub 2013 Sep 25.

DOI:10.1021/la402598p
PMID:24066971
Abstract

We introduce a facile approach for the production of gas-filled microcapsules designed to withstand high pressures. We exploit microfluidics to fabricate water-filled microcapsules that are then externally triggered to become gas-filled, thus making them more echogenic. In addition, the gas-filled microcapsules have a solid polymer shell making them resistant to pressure-induced buckling, which makes them more mechanically robust than traditional prestabilized microbubbles; this should increase the potential of their utility for acoustic imaging of porous media with high hydrostatic pressures such as oil reservoirs.

摘要

我们介绍了一种生产可承受高压的充气微胶囊的简便方法。我们利用微流控技术制造充水微胶囊,然后通过外部触发将其变为充气微胶囊,从而提高其超声反射性。此外,充气微胶囊具有固体聚合物外壳,可抵抗压力引起的屈曲,使其比传统的预稳定微泡更具机械强度;这应该增加它们在具有高静水压力(如油藏)的多孔介质声成像中的应用潜力。

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