• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

具有收缩连续相入口的改进型流动聚焦微通道设计及流体流动特性研究

Design of Improved Flow-Focusing Microchannel with Constricted Continuous Phase Inlet and Study of Fluid Flow Characteristics.

作者信息

Wang Zhaohui, Ding Weibing, Fan Yiwei, Wang Jian, Chen Jie, Wang Hongxia

机构信息

Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of Education, Wuhan University of Science and Technology, Wuhan 430081, China.

The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China.

出版信息

Micromachines (Basel). 2022 Oct 19;13(10):1776. doi: 10.3390/mi13101776.

DOI:10.3390/mi13101776
PMID:36296129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9609089/
Abstract

This paper proposed an improved flow-focusing microchannel with a constricted continuous phase inlet to increase microbubble generation frequency and reduce microbubbles' diameter. The design variables were obtained by Latin hypercube sampling, and the radial basis function (RBF) surrogate model was used to establish the relationship between the objective function (microbubble diameter and generation frequency) and the design variables. Moreover, the optimized design of the nondominated sorting genetic algorithm II (NSGA-II) algorithm was carried out. Finally, the optimization results were verified by numerical simulations and compared with those of traditional microchannels. The results showed that dripping and squeezing regimes existed in the two microchannels. The constricted continuous phase inlet enhanced the flow-focusing effect of the improved microchannel. The diameter of microbubbles obtained from the improved microchannel was reduced from 2.8141 to 1.6949 μm, and the generation frequency was increased from 64.077 to 175.438 kHz at the same capillary numbers (Ca) compared with the traditional microchannel. According to the fitted linear function, it is known that the slope of decreasing microbubble diameter with increasing Ca number and the slope of increasing generation frequency with increasing Ca number are greater in the improved microchannel compared with those in the traditional microchannel.

摘要

本文提出了一种改进的流动聚焦微通道,其连续相入口处有收缩结构,以提高微气泡产生频率并减小微气泡直径。通过拉丁超立方抽样获得设计变量,并使用径向基函数(RBF)代理模型建立目标函数(微气泡直径和产生频率)与设计变量之间的关系。此外,还对非支配排序遗传算法II(NSGA-II)算法进行了优化设计。最后,通过数值模拟验证了优化结果,并与传统微通道的结果进行了比较。结果表明,两种微通道中均存在滴状和挤压状流型。收缩的连续相入口增强了改进型微通道的流动聚焦效果。与传统微通道相比,在相同毛细管数(Ca)下,改进型微通道产生的微气泡直径从2.8141μm减小到1.6949μm,产生频率从64.077kHz增加到175.438kHz。根据拟合的线性函数可知,与传统微通道相比,改进型微通道中微气泡直径随Ca数增加而减小的斜率以及产生频率随Ca数增加而增加的斜率更大。

相似文献

1
Design of Improved Flow-Focusing Microchannel with Constricted Continuous Phase Inlet and Study of Fluid Flow Characteristics.具有收缩连续相入口的改进型流动聚焦微通道设计及流体流动特性研究
Micromachines (Basel). 2022 Oct 19;13(10):1776. doi: 10.3390/mi13101776.
2
Study on Flow Characteristics of Working Medium in Microchannel Simulated by Porous Media Model.基于多孔介质模型模拟微通道内工作介质流动特性的研究
Micromachines (Basel). 2020 Dec 26;12(1):18. doi: 10.3390/mi12010018.
3
The Surfactant Role on a Droplet Passing through a Constricted Microchannel in a Pressure-Driven Flow: A Lattice Boltzmann Study.压力驱动流中表面活性剂对液滴通过收缩微通道的作用:格子玻尔兹曼研究
Langmuir. 2023 Sep 26;39(38):13735-13747. doi: 10.1021/acs.langmuir.3c02003. Epub 2023 Sep 13.
4
A flow map for core/shell microdroplet formation in the co-flow Microchannel using ternary phase-field numerical model.三相流中空微通道中核壳结构微液滴形成的流型图:使用三相相场数值模型。
Sci Rep. 2022 Dec 20;12(1):22010. doi: 10.1038/s41598-022-26648-3.
5
Optimal Design of Nanoparticle Enhanced Phan-Thien-Tanner Flow of a Viscoelastic Fluid in a Microchannel.微通道中纳米颗粒增强的粘弹性流体的Phan-Thien-Tanner流动的优化设计
Entropy (Basel). 2018 Nov 22;20(12):895. doi: 10.3390/e20120895.
6
A Novel Manifold Dual-Microchannel Flow Field Structure with High-Performance Heat Dissipation.一种具有高性能散热的新型流形双微通道流场结构
Micromachines (Basel). 2022 Aug 28;13(9):1420. doi: 10.3390/mi13091420.
7
Viscoelastic effects on electrokinetic particle focusing in a constricted microchannel.粘弹性对微通道受限区域电动颗粒聚焦的影响。
Biomicrofluidics. 2015 Jan 22;9(1):014108. doi: 10.1063/1.4906798. eCollection 2015 Jan.
8
Numerical simulation of heat transfer and flow of AlO-water nanofluid in microchannel heat sink with cantor fractal structure based on genetic algorithm.基于遗传算法的具有 Cantor 分形结构的微通道热沉中 AlO-水纳米流体传热与流动的数值模拟。
Anal Chim Acta. 2022 Aug 15;1221:339927. doi: 10.1016/j.aca.2022.339927. Epub 2022 May 14.
9
Numerical Study on the Fluid Flow and Heat Transfer Characteristics of AlO-Water Nanofluids in Microchannels of Different Aspect Ratio.不同纵横比微通道中AlO-水纳米流体的流动与传热特性的数值研究
Micromachines (Basel). 2021 Jul 24;12(8):868. doi: 10.3390/mi12080868.
10
Experimental Study and Mechanism Analysis of the Flow Boiling and Heat Transfer Characteristics in Microchannels with Different Surface Wettability.不同表面润湿性微通道内流动沸腾与传热特性的实验研究及机理分析
Micromachines (Basel). 2021 Jul 27;12(8):881. doi: 10.3390/mi12080881.

本文引用的文献

1
Production rate and diameter analysis of spherical monodisperse microbubbles from two-dimensional, expanding-nozzle flow-focusing microfluidic devices.二维扩展喷嘴流聚焦微流控装置中单分散球形微泡的生成速率和直径分析。
Biomicrofluidics. 2013 Jan 16;7(1):14103. doi: 10.1063/1.4774069. eCollection 2013.
2
Microfluidic fabrication of stable gas-filled microcapsules for acoustic contrast enhancement.微流控法制备稳定充气体微胶囊用于声对比增强。
Langmuir. 2013 Oct 8;29(40):12352-7. doi: 10.1021/la402598p. Epub 2013 Sep 25.
3
Enhanced intracellular delivery of a model drug using microbubbles produced by a microfluidic device.
利用微流控装置产生的微泡增强模型药物的细胞内递送。
Ultrasound Med Biol. 2013 Jul;39(7):1267-76. doi: 10.1016/j.ultrasmedbio.2013.01.023. Epub 2013 Apr 30.
4
Monodisperse gas-filled microparticles from reactions in double emulsions.由双乳液反应制备单分散含气微球。
Langmuir. 2012 May 1;28(17):6742-5. doi: 10.1021/la300915p. Epub 2012 Apr 20.
5
Microbubble generation in a co-flow device operated in a new regime.在新运行模式下的对流向流装置中产生的微泡。
Lab Chip. 2011 Jun 21;11(12):2023-9. doi: 10.1039/c0lc00731e. Epub 2011 Mar 23.
6
Novel preparation techniques for controlling microbubble uniformity: a comparison.新型制备技术控制微泡均匀性的比较。
Med Biol Eng Comput. 2009 Aug;47(8):883-92. doi: 10.1007/s11517-009-0490-8. Epub 2009 May 12.
7
Bubble formation dynamics in various flow-focusing microdevices.
Langmuir. 2008 Dec 16;24(24):13904-11. doi: 10.1021/la802008k.
8
Role of the channel geometry on the bubble pinch-off in flow-focusing devices.通道几何形状在流动聚焦装置中对气泡 pinch-off 的作用。 (注:pinch-off 直译为“夹断”,在流体力学等领域可能有特定专业含义,这里保留英文以便准确传达原文意思)
Phys Rev Lett. 2008 Jan 25;100(3):034504. doi: 10.1103/PhysRevLett.100.034504.
9
Microbubbling by co-axial electrohydrodynamic atomization.同轴电液动力雾化产生微泡
Med Biol Eng Comput. 2007 Aug;45(8):781-9. doi: 10.1007/s11517-007-0210-1. Epub 2007 Jul 12.
10
Ultrasound contrast agents: an overview.超声造影剂:综述
Eur J Radiol. 2006 Dec;60(3):324-30. doi: 10.1016/j.ejrad.2006.06.022. Epub 2006 Aug 30.