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人类狂犬病防控面临的挑战:黎巴嫩的经验

Challenges facing human rabies control: the Lebanese experience.

作者信息

Bizri A, Alawieh A, Ghosn N, Berry A, Musharrafieh U

机构信息

Division of Infectious Diseases, Department of Internal Medicine,American University of Beirut Medical Center,Beirut,Lebanon.

Faculty of Medicine,American University of Beirut,Beirut,Lebanon.

出版信息

Epidemiol Infect. 2014 Jul;142(7):1486-94. doi: 10.1017/S0950268813002392. Epub 2013 Sep 25.

Abstract

Rabies is one of the most important zoonotic infections worldwide. The burden of the disease continues to be significant in countries in the Middle East where the most important vector is stray dogs. Control efforts are hindered by lack of awareness and incomplete post-exposure prophylaxis. The aim of this article is to re-assess the situation of rabies in Lebanon and compare it to other Middle Eastern countries. Eight cases of rabies and 5280 incidents of animal bites to humans were reported to the Lebanese Ministry of Public Health between 2001 and 2012. Dogs were the only vector of infection and were responsible for most reported animal bites to humans. An average of 3·2 doses of vaccine per bite was administered as post-exposure prophylaxis. The status of human and canine rabies control, the risks associated with children's behaviour and the hazards of secondary wild reservoirs are discussed. Our data illustrates the importance of prevention through vector control, public awareness and education, and timely administration of active and passive immunization, as well as the significance of regional cooperation and monitoring the circulation of viral variants in wild animals.

摘要

狂犬病是全球最重要的人畜共患传染病之一。在中东地区的国家,该病负担依然沉重,其中最重要的传播媒介是流浪狗。由于意识淡薄和暴露后预防措施不完善,防控工作受到阻碍。本文旨在重新评估黎巴嫩的狂犬病状况,并与其他中东国家进行比较。2001年至2012年间,黎巴嫩公共卫生部共报告了8例狂犬病病例和5280起动物咬伤人事件。狗是唯一的感染媒介,也是大多数报告的动物咬伤人事件的起因。暴露后预防平均每咬伤一次接种3.2剂疫苗。本文还讨论了人类和犬类狂犬病的防控状况、儿童行为相关风险以及野生二级宿主的危害。我们的数据表明了通过控制传播媒介、提高公众意识和开展教育、及时进行主动和被动免疫来预防狂犬病的重要性,以及区域合作和监测野生动物中病毒变种传播的意义。

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Challenges facing human rabies control: the Lebanese experience.人类狂犬病防控面临的挑战:黎巴嫩的经验
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本文引用的文献

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Current and future tools for global canine rabies elimination.全球犬狂犬病消除的当前和未来工具。
Antiviral Res. 2013 Oct;100(1):220-5. doi: 10.1016/j.antiviral.2013.07.004. Epub 2013 Jul 18.
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Imported human rabies cases worldwide, 1990-2012.全球 1990-2012 年输入性狂犬病病例。
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