Department of Gynaecologic Surgery, Gustave Roussy, Cancer Campus, Grand Paris, Villejuif, France.
Hum Reprod. 2013 Dec;28(12):3222-6. doi: 10.1093/humrep/det371. Epub 2013 Sep 25.
Here we report the outcomes of 26 patients who relapsed following conservative surgical treatment of stage I serous borderline ovarian tumours treated initially with fertility-sparing surgery. All recurrences were diagnosed by systematic ultrasonography during follow-up. Eleven patients relapsed at least twice after such management. Twenty-one pregnancies were observed in 13 patients. Eleven of these patients became pregnant after the treatment of their first recurrence. All patients had a borderline ovarian tumour and/or non-invasive peritoneal implants at the time of the first recurrence but two of them had invasive ovarian and peritoneal disease at the time of the second or third recurrence (one of them died of disease). Fertility-preserving surgery remains a valuable alternative (if technically feasible), in young patients with recurrent SBOT, in the form of a non-invasive ovarian lesion, who wish to start a pregnancy. However, it should be associated with meticulous follow-up because the risk of progression to carcinoma exists, albeit small.
我们在此报告 26 例接受保留生育功能手术治疗的 I 期浆液性交界性卵巢肿瘤患者的治疗结果。所有复发均通过随访期间的系统超声检查诊断。11 例患者在这种治疗后至少复发了 2 次。13 例患者中有 21 例怀孕。其中 11 例在首次复发后接受治疗后怀孕。所有患者在首次复发时均患有交界性卵巢肿瘤和/或非浸润性腹膜种植，但其中 2 例在第二次或第三次复发时患有浸润性卵巢和腹膜疾病（其中 1 例死于疾病）。对于有生育要求的年轻、复发性 SBOT 患者，保留生育功能的手术仍然是一种有价值的选择（如果技术上可行），前提是肿瘤为非浸润性卵巢病变。然而，应该进行仔细的随访，因为存在进展为癌的风险，尽管很小。
