Chan John K, Lin Yvonne G, Loizzi Vera, Ghobriel Mariam, DiSaia Philip J, Berman Michael L
Division of Gynecologic Oncology, Chao Family Comprehensive Cancer Center, University of California, Irvine, Medical Center, Orange, USA.
J Reprod Med. 2003 Oct;48(10):756-60.
To evaluate the fertility and survival outcomes in young women with borderline ovarian tumors treated with fertility-sparing surgery.
From 1985 to 2002, 25 women with borderline ovarian cancers surgically managed with preservation of the uterus and at least a portion of 1 ovary were identified from tumor registry databases at 2 southern California hospitals. Data for analysis were collected from hospital charts, office records and tumor registry files.
Twenty-five patients (median age, 29 years) with borderline ovarian tumors, including 10 with stage IA, 3 with stage IC, 1 with stage IIIA and 11 with unstaged disease, underwent fertility-sparing surgery, consisting of unilateral adnexectomy in 19, unilateral adnexectomy with contralateral cystectomy in 5 and unilateral cystectomy in 1. No disease recurred, providing an overall survival of 100%. Fertility status was available on 15 patients 4-157 months after surgery; 6 of them attempted to become pregnant. Five women had successful pregnancies, with a total of 5 live births. One woman underwent assisted reproductive techniques, became pregnant but aborted. The median follow-up was 80 months (range, 4-157).
Conservative surgery for borderline ovarian tumors should be considered for women in the reproductive age group who desire preservation of fertility.
评估采用保留生育功能手术治疗的年轻卵巢交界性肿瘤患者的生育及生存结局。
从1985年至2002年，从南加州两家医院的肿瘤登记数据库中识别出25例接受了保留子宫及至少部分一侧卵巢的手术治疗的卵巢交界性癌患者。分析数据收集自医院病历、门诊记录及肿瘤登记档案。
25例（中位年龄29岁）卵巢交界性肿瘤患者，包括10例IA期、3例IC期、1例IIIA期及11例分期不明疾病患者，接受了保留生育功能手术，其中19例行单侧附件切除术，5例行单侧附件切除术加对侧囊肿切除术，1例行单侧囊肿切除术。无疾病复发，总生存率为100%。15例患者在术后4至157个月有生育状况记录；其中6例尝试怀孕。5名女性成功怀孕，共分娩5名活婴。1名女性接受辅助生殖技术后怀孕但流产。中位随访时间为80个月（范围4至157个月）。
对于希望保留生育功能的育龄期女性，应考虑对卵巢交界性肿瘤进行保守性手术。
