Kong Lingling, Zhang Guoan, Wang Xu, Zhou Jian, Hou Sen, Cui Wen
Department of Pathology, Basic Science School, Jining Medical University, Jining, Shandong, China;
Rom J Morphol Embryol. 2013;54(3):499-503.
To investigate the prognostic significance of LSD1 and RBP2 expression in patients with papillary thyroid carcinoma.
LSD1 and RBP2 expressions were detected by immunohistochemistry in surgically resected samples from thyroid adenoma, papillary thyroid carcinoma and paracancerous tissues.
To be members of histone demethylases, LSD1 and RBP2 were both localized mainly to the thyroid cell nucleus. Despite the fact that both RBP2 and LSD1 expressions were higher in papillary thyroid carcinoma than in paracancerous tissues (U=-3.855, p=0.000; U=-5.575, p=0.000) and thyroid adenoma (U=-1.972, p=0.049; U=-3.190, p=0.001), they did not show us statistical correlation (r=-0.149, p=0.270). Like LSD1 (U=-2.286, p=0.022), RBP2 expression was less frequently in paracancerous tissues than in thyroid adenoma (U=-1.985, p=0.047). Neither LSD1 nor RBP2 expression was significantly associated with age, gender, stage status, tumor size, and lymph node metastases (p>0.05).
Both LSD1 and RBP2 are well related with the occurrence and malignant transformation of papillary thyroid carcinoma. Though the positive expression of both LSD1 and RBP2 can be used to estimate the potentiality of thyroid carcinoma and help for the adjuvant treatment, LSD1 is a more sensitive molecular marker than RBP2 on thyroid cancer diagnosis.
探讨赖氨酸特异性去甲基化酶1（LSD1）和视网膜母细胞瘤结合蛋白2（RBP2）在甲状腺乳头状癌患者中的预后意义。
采用免疫组织化学法检测甲状腺腺瘤、甲状腺乳头状癌及癌旁组织手术切除标本中LSD1和RBP2的表达。
作为组蛋白去甲基化酶成员，LSD1和RBP2均主要定位于甲状腺细胞核。尽管RBP2和LSD1在甲状腺乳头状癌中的表达均高于癌旁组织（U=-3.855，p=0.000；U=-5.575，p=0.000）和甲状腺腺瘤（U=-1.972，p=0.049；U=-3.190，p=0.001），但二者无统计学相关性（r=-0.149，p=0.270）。与LSD1（U=-2.286，p=0.022）相似，RBP2在癌旁组织中的表达低于甲状腺腺瘤（U=-1.985，p=0.047）。LSD1和RBP2的表达均与年龄、性别、分期、肿瘤大小及淋巴结转移无显著相关性（p>0.05）。
LSD1和RBP2均与甲状腺乳头状癌的发生及恶性转化密切相关。虽然LSD1和RBP2的阳性表达均可用于评估甲状腺癌的潜能并辅助治疗，但在甲状腺癌诊断中，LSD1是比RBP2更敏感的分子标志物。
