Streba Liliana, Gruia Corina, Mogoantă S S, Mitruţ P, Streba Letiţia Adela-Maria, Bold Adriana
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2013;54(3):629-34.
The presence of synchronous multiple primary carcinomas, although recognized, remains very uncommon. Their etiopathogeny is unclear. The wide spread of imaging techniques currently facilitates diagnosis of simultaneous tumors. We present the rare case of a signet ring cell colon carcinoma coexisting with a transitional cell carcinoma (TCC) of the ureter, which debuted with symptoms of intestinal obstruction in a 75-year-old male patient, with no prior relevant history. Computed tomography showed signs of a tumor mass on the transverse colon, as well as left hydronephrosis with a tumor in the lower third of the ureter, which prompted for immediate emergency surgery. After the appropriate surgical maneuvers, tissue collected from both tumors underwent usual histological preparation and Hematoxylin-Eosin staining, as well as multiple immunostaining with a complex panel of markers. The patient had a favorable postoperative course and during a six-month follow-up, we did not detect any signs of illness.
同步性多原发性癌的存在虽然已被认识到，但仍然非常罕见。其病因尚不清楚。目前成像技术的广泛应用有助于同时性肿瘤的诊断。我们报告了一例罕见病例，一名75岁男性患者，既往无相关病史，以肠梗阻症状初诊，其结肠印戒细胞癌与输尿管移行细胞癌（TCC）并存。计算机断层扫描显示横结肠有肿瘤肿块迹象，以及左肾积水伴输尿管下三分之一处有肿瘤，这促使立即进行急诊手术。经过适当的手术操作后，从两个肿瘤采集的组织进行了常规组织学制备和苏木精-伊红染色，以及使用一组复杂标志物进行多重免疫染色。患者术后病程良好，在六个月的随访期间，我们未发现任何疾病迹象。
