Institut National de la Santé et de la Recherche Médicale (INSERM) , UMR989, Paris , France.
Int Rev Immunol. 2013 Oct-Dec;32(5-6):475-92. doi: 10.3109/08830185.2013.829471. Epub 2013 Sep 26.
T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induction and functional heterogeneity of Th17 responses, the underlying molecular effects of Th17 response including the most relevant different cell targets of Th17 cytokines remain poorly understood. Cytokines produced by Th17 cells have broad effects on both hematopoietic and nonhematopoietic cells and can act in synergy with various inflammatory factors. In this review, we will focus on the effects of Th17-derived cytokines in the gastrointestinal tract and discuss how Th17 responses can affect both innate and adaptive immunity and may contribute to the pathogenesis of inflammatory GI processes.
辅助性 T 细胞 17（TH17）的激活对于黏膜表面抵抗细菌和真菌的保护性免疫反应至关重要，但它也可能与几种自身免疫和慢性炎症性疾病的发病机制有关，如炎症性肠病（IBD）。尽管在阐明 Th17 反应的诱导和功能异质性方面取得了快速进展，但 Th17 反应的潜在分子效应，包括 Th17 细胞因子的最相关不同细胞靶点，仍知之甚少。Th17 细胞产生的细胞因子对造血细胞和非造血细胞都有广泛的影响，并能与各种炎症因子协同作用。在这篇综述中，我们将重点讨论 Th17 细胞衍生的细胞因子在胃肠道中的作用，并讨论 Th17 反应如何影响先天和适应性免疫，以及可能有助于炎症性 GI 过程的发病机制。
