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北美三尖瓣手术的趋势和结果:来自胸外科医生学会数据库的超过 50000 例患者的分析。

Trends and outcomes of tricuspid valve surgery in North America: an analysis of more than 50,000 patients from the Society of Thoracic Surgeons database.

机构信息

Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland.

出版信息

Ann Thorac Surg. 2013 Nov;96(5):1546-52; discussion 1552. doi: 10.1016/j.athoracsur.2013.06.031. Epub 2013 Sep 23.

Abstract

BACKGROUND

This study evaluated trends and outcomes of tricuspid valve surgery (TVS) in North America over the past decade.

METHODS

Adults undergoing TVS between 2000 and 2010 were identified in The Society of Thoracic Surgeons (STS) National Database. Trends were evaluated using linear regression. Multivariable logistic regression analysis was conducted using covariates from the STS valve risk model to identify significant predictors of operative mortality.

RESULTS

A total of 54,375 patients underwent TVS during the study period. The majority of cases were repairs (89%; n = 48,322) and were performed concomitant with another major procedure (86%; n = 46,593). The proportion of TVS that were repairs increased from 84.6% in 2000 to 89.8% in 2010 (p = 0.01). Trend analysis revealed significant changes in patient characteristics with time, including increasing age, a higher comorbidity burden, and a higher proportion of emergency cases. Despite worsening risk factors, unadjusted operative mortality for TVS declined from 10.6% in 2000 to 8.2% in 2010 (p < 0.001), and this trend persisted after risk adjustment. In the multivariable model, concomitant procedures involving multiple valves or coronary artery bypass grafting were associated with an increased risk of mortality compared with isolated TVS, although other factors including renal failure, congestive heart failure, nonelective presentation, reoperation, and tricuspid valve replacement exerted equal or stronger effects.

CONCLUSIONS

During the past decade, repair rates for TVS have increased significantly. Although patients undergoing TVS have demonstrated worsening risk factors, unadjusted and adjusted operative mortalities have declined. Finally, the data suggest that tricuspid valve repair when technically feasible, together with early elective surgical intervention, should be emphasized as potential candidates for continued outcome improvement.

摘要

背景

本研究评估了过去十年北美三尖瓣手术(TVS)的趋势和结果。

方法

在胸外科医师学会(STS)国家数据库中确定了 2000 年至 2010 年间接受 TVS 的成年人。使用线性回归评估趋势。使用 STS 瓣膜风险模型中的协变量进行多变量逻辑回归分析,以确定手术死亡率的显著预测因素。

结果

在研究期间,共有 54375 例患者接受了 TVS。大多数病例为修复术(89%;n=48322),并与另一项主要手术同时进行(86%;n=46593)。修复术在 TVS 中的比例从 2000 年的 84.6%增加到 2010 年的 89.8%(p=0.01)。趋势分析显示,随着时间的推移,患者特征发生了显著变化,包括年龄增加、合并症负担加重以及急诊病例比例增加。尽管风险因素恶化,但 TVS 的未调整手术死亡率从 2000 年的 10.6%下降到 2010 年的 8.2%(p<0.001),并且这种趋势在风险调整后仍然存在。在多变量模型中,与孤立的 TVS 相比,涉及多个瓣膜或冠状动脉旁路移植术的联合手术与死亡率增加相关,尽管其他因素,如肾衰竭、充血性心力衰竭、非择期就诊、再次手术和三尖瓣置换术,也具有同等或更强的影响。

结论

在过去十年中,TVS 的修复率显著增加。尽管接受 TVS 的患者表现出风险因素恶化,但未调整和调整后的手术死亡率均有所下降。最后,数据表明,当技术可行时,应强调三尖瓣修复术,以及早期择期手术干预,作为持续改善结果的潜在候选者。

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