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部分龋坏组织去除可能具有优势,但关于修复体存留的证据有限。

Partial caries removal may have advantages but limited evidence on restoration survival.

作者信息

Manton David

机构信息

Department of Child Dental Health, Melbourne Dental School, The University of Melbourne, Melbourne, Australia.

出版信息

Evid Based Dent. 2013 Sep;14(3):74-5. doi: 10.1038/sj.ebd.6400948.

Abstract

DATA SOURCES

Cochrane Oral Health Group's Trials Register, CENTRAL, Medline via OVID, EMBASE via OVID; no restrictions on language or date of publication.

STUDY SELECTION

Parallel group and split mouth randomised and quasi-randomised controlled trials comparing stepwise, partial and no dentinal caries removal with complete caries removal in unrestored primary and permanent teeth were included in this review.

DATA EXTRACTION AND SYNTHESIS

Title and abstract screening was by two reviewers, with disagreements resolved by a third. Full texts of eligible studies were assessed by the team until consensus, and data extraction was by three reviewers independently and in triplicate. Two reviewers assessed risk of bias. Trial authors were contacted where possible .

RESULTS

Eight trials (all assessed as high risk of bias) with 934 participants and 1372 teeth were included in this updated review (Previously complete or ultraconservative removal of decayed tissue in unfilled teeth, Ricketts, 2006) with four new trials being included. There were a number of different comparisons in the trials (stepwise or partial or no dentinal caries removal compared to complete caries removal) with one study including more than one of these comparisons. Four studies investigated primary teeth, three permanent teeth and one included both.For stepwise caries removal, (four studies), there was a 56% reduction in incidence of pulp exposure (RR 0.44, 95% CI 0.33 to 0.60, P < 0.00001) compared to complete caries removal. The mean pulp exposure incidence was 34.7% in the complete caries removal group and 15.4% in the stepwise groups. There was no difference in signs and symptoms of pulp disease (RR 0.78, 95% CI 0.39 to 1.58, P = 0.50).In the two partial caries removal studies, the incidence of pulp exposure reduction was 77% for the partial caries removal group (RR 0.23, 95% CI 0.08 to 0.69, P = 0.009) with a mean pulp exposure incidence of 21.9% in the complete caries removal groups and 5% in the partial caries removal groups. There was insufficient evidence to determine whether or not there was a difference in signs and symptoms of pulp disease (RR 0.27, 95% CI 0.05 to 1.60, P = 0.15), or restoration failure (one study showing no difference and another study showing no failures in either group).There were two very different studies which looked at no dentinal caries removal compared to complete caries removal. There was some evidence of no difference between these techniques for the outcome of signs and symptoms of pulp disease and reduced risk of restoration failure, favouring no dentinal caries removal, from one study. There were no instances of pulp disease or restoration failure in either group from the second study. Meta-analysis of these two studies was not carried out because of the substantial clinical differences between the studies.

CONCLUSIONS

For management of dentinal caries, both stepwise and partial excavation showed clinical advantage over complete caries removal by reducing the incidence of pulp exposure in symptomless, vital, carious primary as well as permanent teeth. The review found no difference in signs or symptoms of pulpal disease between stepwise excavation and complete caries removal.There was insufficient evidence to determine whether there was a difference in signs and symptoms of pulp disease or a difference in the risk of restoration failure with partial caries removal.For the two no dentinal caries removal studies, the one investigating permanent teeth found no difference in restoration failure and the one investigating primary teeth found a statistically significant difference in restoration failure favouring the intervention.Due to the short term follow-up, low reporting of patient centred outcomes and high risk of bias, further high quality, long-term clinical trials are still required to assess the most effective intervention.

摘要

数据来源

Cochrane口腔健康组试验注册库、Cochrane系统评价数据库、通过OVID检索的Medline数据库、通过OVID检索的EMBASE数据库;对语言和出版日期无限制。

研究选择

本综述纳入了平行组、半口随机和半口准随机对照试验,这些试验比较了在未修复的乳牙和恒牙中,逐步、部分和不进行牙本质龋去除与完全龋去除的效果。

数据提取与综合分析

两名评审员对标题和摘要进行筛选,如有分歧则由第三名评审员解决。符合条件的研究全文由研究团队评估直至达成共识,数据提取由三名评审员独立进行,共提取三次。两名评审员评估偏倚风险。如有可能,会与试验作者进行联系。

结果

本次更新综述纳入了八项试验(所有试验均被评估为高偏倚风险),涉及934名参与者和1372颗牙齿(之前的研究为Ricketts于2006年进行的未填充牙齿中龋坏组织的完全或超保守去除),其中纳入了四项新试验。试验中有多种不同的比较(逐步或部分或不进行牙本质龋去除与完全龋去除相比),一项研究包含了不止一种此类比较。四项研究调查了乳牙,三项研究调查了恒牙,一项研究同时包含了乳牙和恒牙。对于逐步龋去除(四项研究),与完全龋去除相比,牙髓暴露发生率降低了56%(风险比0.44,95%置信区间0.33至0.60,P<0.00001)。完全龋去除组的平均牙髓暴露发生率为34.7%,逐步龋去除组为15.4%。牙髓疾病的体征和症状无差异(风险比0.78,9�%置信区间0.39至1.58,P = 0.50)。在两项部分龋去除研究中,部分龋去除组的牙髓暴露发生率降低了77%(风险比0.23,95%置信区间0.08至0.69,P = 0.009),完全龋去除组的平均牙髓暴露发生率为21.9%,部分龋去除组为5%。没有足够的证据来确定牙髓疾病的体征和症状是否存在差异(风险比0.27,95%置信区间0.05至1.60,P = 0.15),或者修复失败是否存在差异(一项研究显示无差异,另一项研究显示两组均无失败情况)。有两项研究对比了不进行牙本质龋去除与完全龋去除的情况,二者差异很大。一项研究表明,在牙髓疾病体征和症状的结果以及降低修复失败风险方面,这些技术之间没有差异,支持不进行牙本质龋去除。第二项研究中两组均未出现牙髓疾病或修复失败的情况。由于这两项研究在临床方面存在实质性差异,因此未对其进行荟萃分析。

结论

对于牙本质龋的治疗,逐步和部分龋洞预备在无症状、活力正常的龋坏乳牙和恒牙中,通过降低牙髓暴露发生率,显示出比完全龋去除更具临床优势。综述发现逐步龋洞预备和完全龋去除在牙髓疾病的体征或症状方面没有差异。没有足够的证据来确定部分龋去除在牙髓疾病的体征和症状方面是否存在差异,或者在修复失败风险方面是否存在差异。对于两项不进行牙本质龋去除的研究,一项研究调查恒牙发现修复失败无差异,另一项研究调查乳牙发现修复失败在干预组具有统计学意义的差异。由于随访时间短、以患者为中心的结局报告率低以及偏倚风险高,仍需要进一步开展高质量、长期的临床试验来评估最有效的干预措施。

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